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We describe the case of a woman in her late 20s with pruritic erythema on the chest that manifested in the luteal phase of the menstrual cycle, with spontaneous resolution in less than 5\u2009days, without secondary scarring. The histological diagnosis was non-specific, with evidence of interface dermatitis, but positive skin tests supported the diagnosis of autoimmune progesterone dermatitis. It is intended to alert to the manifestations of a pathology that is rare and difficult to diagnose but with a great impact on daily life.<\/jats:p>","DOI":"10.1136\/bcr-2023-256353","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T12:45:24Z","timestamp":1700743524000},"page":"e256353","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Progesterone hypersensitivity: a cyclical history"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-1823","authenticated-orcid":false,"given":"Rute","family":"Br\u00e1s-Cruz","sequence":"first","affiliation":[{"name":"Internal Medicine, Hospital Pedro Hispano, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8299-5747","authenticated-orcid":false,"given":"Filipa","family":"David","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hospital Pedro Hispano, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rute","family":"Morais Ferreira","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hospital Pedro Hispano, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ros\u00e1rio","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hospital Pedro Hispano, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"2025082801220690000_16.11.e256353.1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2133.1939.tb10741.x","article-title":"Desensitization in the treatment of menstrual intoxication and other allergic symptoms","volume":"51","author":"Geber","year":"1939","journal-title":"Br J Dermatol"},{"key":"2025082801220690000_16.11.e256353.2","unstructured":"Shelley WB , Preucel RW , Spoont SS . 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