{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:10:17Z","timestamp":1756278617390,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,19]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Pheochromocytoma is a chromaffin cell-derived adrenal medullary tumour and usually presents with paroxysms of hypertension, palpitations, sweating and headache due to excessive catecholamine release. These tumours can also secrete a variety of bioactive neuropeptides and hormones other than catecholamines, resulting in unusual clinical manifestations. We report a female in her mid-30s who presented with fever, anaemia, thrombocytosis and markedly elevated inflammatory markers. The fever profile, including cultures, was negative. Contrast-enhanced CT of abdomen showed a large solid-cystic right adrenal lesion with elevated plasma-free normetanephrine levels suggestive of pheochromocytoma. The fever persisted despite empirical antibiotics and antipyretics. Interleukin-6 (IL-6) levels were elevated (41.2 pg\/mL (3\u20134\u2009pg\/mL)). She was initiated on naproxen (NPX) at a dose of 250 mg two times per day. The patient responded to NPX, and after stabilisation, she underwent an adrenalectomy. There was a complete resolution of fever with normalisation of IL-6 levels postoperatively.<\/jats:p>","DOI":"10.1136\/bcr-2023-256410","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T02:00:14Z","timestamp":1714096814000},"page":"e256410","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated IL-6 levels in a patient with pheochromocytoma"],"prefix":"10.1136","volume":"17","author":[{"given":"Mahesh","family":"Hakke","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College & BYL Nair Ch. Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil M","family":"Bhagwat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College & BYL Nair Ch. Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jugal Velji","family":"Gada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College & BYL Nair Ch. Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukirti","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College & BYL Nair Ch. 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