{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:04:22Z","timestamp":1756425862001,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,3]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Shiga toxin (Stx)-producing <jats:italic>Escherichia coli<\/jats:italic>-mediated haemolytic uraemic syndrome is a primary thrombotic microangiopathy, typified by the development of microangiopathic haemolytic anaemia, thrombocytopaenia and acute renal failure. It is a leading cause of acute renal failure in paediatrics, with a second peak in prevalence in adults over the age of 60. Presentations of Stx-producing <jats:italic>E. coli<\/jats:italic>-mediated haemolytic uraemic syndrome in young adults are rare. We present the case of a previously well female in her early 30s presenting with Stx-producing <jats:italic>E. coli-<\/jats:italic>mediated haemolytic uraemic syndrome with severe renal and neurological manifestations. Eculizumab was administered due to the severity of presentation and disease trajectory refractory to initial supportive therapy. A significant clinical and biochemical improvement was observed following eculizumab.<\/jats:p>","DOI":"10.1136\/bcr-2023-256524","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T19:45:18Z","timestamp":1705607118000},"page":"e256524","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Eculizumab in severe Shiga toxin-mediated haemolytic uraemic syndrome"],"prefix":"10.1136","volume":"17","author":[{"given":"Mitchell","family":"Carroll","sequence":"first","affiliation":[{"name":"General Medicine, Grampians Health Ballarat, Ballarat, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Blake","sequence":"additional","affiliation":[{"name":"General Medicine, Barwon Health, Geelong, Victoria, 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