{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:54Z","timestamp":1756425834303,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,9,17]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>We report an interesting case of pericardial effusion associated with idiopathic systemic capillary leak syndrome (ISCLS) following administration of SARS-CoV-2 vaccine. This patient initially presented with dyspnoea and chest pain, with non-pitting oedema and clear lung fields. The diagnosis of ISCLS was made based on the clinical syndrome and laboratory evidence of polycythaemia and hypoalbuminaemia. An enlarging pericardial effusion was diagnosed on transthoracic echocardiogram. Daily point-of-care ultrasound (POCUS)-guided volume management and serial transthoracic echocardiograms contributed to avoidance of refractory shock, cardiac tamponade and critical care admission.<\/jats:p>","DOI":"10.1136\/bcr-2023-256527","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:01:54Z","timestamp":1696856514000},"page":"e256527","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Pericardial effusion and systemic capillary leak syndrome late post-SARS-CoV-2 vaccination"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-1002","authenticated-orcid":false,"given":"Cathevine","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael YC","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie N","family":"Zypchen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"2025082802514442000_16.10.e256527.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(60)90018-8"},{"key":"2025082802514442000_16.10.e256527.2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jaci.2016.10.042","article-title":"Idiopathic systemic capillary leak syndrome (Clarkson disease)","volume":"140","author":"Druey","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2025082802514442000_16.10.e256527.3","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.amjmed.2017.05.023","article-title":"Intravenous Immunoglobulins improve survival in monoclonal gammopathy-associated systemic capillary-leak syndrome","volume":"130","author":"Pineton de Chambrun","year":"2017","journal-title":"Am J Med"},{"key":"2025082802514442000_16.10.e256527.4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jcrc.2020.01.014","article-title":"Myocardial edema in paroxysmal permeability disorders: the paradigm of Clarkson's disease","volume":"57","author":"Wu","year":"2020","journal-title":"J Crit Care"},{"key":"2025082802514442000_16.10.e256527.5","first-page":"1","article-title":"A case report of capillary leak syndrome with recurrent pericardial and pleural effusions","volume":"4","author":"Khan","year":"2020","journal-title":"Eur Heart J Case Rep"},{"key":"2025082802514442000_16.10.e256527.6","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1093\/rheumatology\/keaa606","article-title":"A new diagnosis of systemic capillary leak syndrome in a patient with COVID-19","volume":"60","author":"Lacout","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2025082802514442000_16.10.e256527.7","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/j.chest.2020.06.049","article-title":"Systemic capillary leak syndrome secondary to coronavirus disease 2019","volume":"158","author":"Case","year":"2020","journal-title":"Chest"},{"key":"2025082802514442000_16.10.e256527.8","doi-asserted-by":"crossref","first-page":"e663","DOI":"10.1016\/j.amjmed.2020.03.057","article-title":"SARS-Cov-2 induces acute and refractory relapse of systemic capillary leak syndrome (Clarkson\u2019s disease)","volume":"133","author":"Pineton de Chambrun","year":"2020","journal-title":"Am J Med"},{"key":"2025082802514442000_16.10.e256527.9","unstructured":"European Medicines Agency Press . Vaxzevria: EMA advises against use in people with history of capillary leak syndrome. 2021. Available: https:\/\/www.ema.europa.eu\/en\/news\/vaxzevria-ema-advises-against-use-people-history-capillary-leak-syndrome [Accessed 11 Jun 2021]."},{"key":"2025082802514442000_16.10.e256527.10","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.7326\/L21-0250","article-title":"Severe exacerbations of systemic capillary leak syndrome after COVID-19 vaccination: a case series","volume":"174","author":"Matheny","year":"2021","journal-title":"Ann Intern Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-256527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:51:54Z","timestamp":1756374714000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-256527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":10,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10,9]]},"published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1136\/bcr-2023-256527"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-256527","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}