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Extended history taking, blood and urine testing (including cardiac biomarkers) identified no evidence of systemic amyloidosis-induced organ dysfunction.<\/jats:p>\n               <jats:p>Primary cerebral AL amyloidoma is a very rare entity where optimal treatment is difficult to assess. The patient was treated with locally applied volumetric modulated arc radiotherapy, 24 Gy, divided in 12 fractions. Afterwards, the paresis of the left arm partially resolved, and the function of the left leg improved. Seizures did not occur anymore.<\/jats:p>","DOI":"10.1136\/bcr-2023-256537","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T02:05:21Z","timestamp":1706148321000},"page":"e256537","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Primary cerebral immunoglobulin light chain amyloidoma in a patient with multiple sclerosis"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-7995","authenticated-orcid":false,"given":"Marissa J M","family":"Traets","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Sint Antonius Hospital, Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisna","family":"Chuwonpad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sint Antonius Hospital, Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roos J","family":"Leguit","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan T F M","family":"Frequin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sint Antonius Hospital, Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique C","family":"Minnema","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Medical Centre, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"2025082707310529000_17.1.e256537.1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13169"},{"key":"2025082707310529000_17.1.e256537.2","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2020.1835263"},{"key":"2025082707310529000_17.1.e256537.3","doi-asserted-by":"crossref","first-page":"107348","DOI":"10.1016\/j.carpath.2021.107348","article-title":"Endomyocardial biopsy with co-localization of a lymphoplasmacytic lymphoma and al amyloidosis","volume":"53","author":"Leguit","year":"2021","journal-title":"Cardiovasc Pathol"},{"key":"2025082707310529000_17.1.e256537.4","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23413"},{"key":"2025082707310529000_17.1.e256537.5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12883-019-1274-x","article-title":"Primary brain amyloidoma, both a neoplastic and a neurodegenerative disease: a case report","volume":"19","author":"L\u00f6hr","year":"2019","journal-title":"BMC Neurol"},{"key":"2025082707310529000_17.1.e256537.6","doi-asserted-by":"publisher","DOI":"10.1080\/13506120600960585"},{"key":"2025082707310529000_17.1.e256537.7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3171\/2016.7.JNS1690","article-title":"A rare case of central nervous system amyloidoma treated with fractionated radiotherapy","volume":"127","author":"Meier","year":"2017","journal-title":"J Neurosurg"},{"key":"2025082707310529000_17.1.e256537.8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz144"},{"key":"2025082707310529000_17.1.e256537.9","doi-asserted-by":"crossref","unstructured":"Yakupova EI , Bobyleva LG , Vikhlyantsev IM , et al . 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