{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:05:20Z","timestamp":1776402320720,"version":"3.51.2"},"reference-count":25,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,12,29]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>A postmenopausal female patient presented with vaginal bleeding. Initial bloodwork revealed an elevated serum beta human chorionic gonadotropin level (\u03b2-hCG). Pelvic MRI identified a complex heterogeneous uterine mass with central necrosis. She underwent total abdominal hysterectomy with bilateral saplingo-oopherectomy. Pathology reported a malignant perivascular epithelioid cell tumour (PEComa). Postoperatively, her \u03b2-hCG level returned to normal. \u03b2-hCG secreting sarcomas are extremely rare, and to our knowledge, there has only been one previously reported case of a \u03b2-hCG secreting PEComa. Based on the limited literature, these tumours may have a worse prognosis. The role of \u03b2-hCG as a marker of treatment response and disease activity is unclear. Additional studies are required to further ascertain its role as a predictive and prognostic biomarker.<\/jats:p>","DOI":"10.1136\/bcr-2023-256641","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:06:31Z","timestamp":1705064791000},"page":"e256641","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["\u03b2-hCG secreting uterine PEComa"],"prefix":"10.1136","volume":"17","author":[{"given":"Patrick","family":"Murphy","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada"},{"name":"Medical Oncology, Mount Sinai Hospital PLM, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Machlab","sequence":"additional","affiliation":[{"name":"Medical Oncology, Mount Sinai Hospital PLM, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahd","family":"Almohsen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada"},{"name":"Pathology, Mount Sinai Hospital PLM, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Fratesi","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1962-7893","authenticated-orcid":false,"given":"Geoffrey","family":"Watson","sequence":"additional","affiliation":[{"name":"Medical Oncology, Mount Sinai Hospital PLM, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"2025082712222063000_17.1.e256641.1","doi-asserted-by":"publisher","DOI":"10.3109\/00313029109063563"},{"key":"2025082712222063000_17.1.e256641.2","doi-asserted-by":"crossref","unstructured":"Trent JC . 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