{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:10:05Z","timestamp":1756368605938,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,11,11]]},"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>There is limited information about sodium valproate-induced hyperammonaemia encephalopathy (VPAIHE). The aim of this case report is to provide medical practitioners with a greater awareness of the possible development of hyperammonaemia due to sodium valproate use and its associated complications.<\/jats:p>\n               <jats:p>This paper describes a middle-aged man with a history of bipolar affective disorder who was admitted with a manic relapse secondary to medication non-compliance. His admission was complicated by an intensive care unit admission to manage medical compromise in the context of sodium VPAIHE.<\/jats:p>","DOI":"10.1136\/bcr-2023-256796","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T09:15:23Z","timestamp":1701335723000},"page":"e256796","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Unusual case of sodium valproate-induced hyperammonaemia encephalopathy"],"prefix":"10.1136","volume":"16","author":[{"given":"Shristhi","family":"Ranjith","sequence":"first","affiliation":[{"name":"Psychiatry, Gold Coast University Hospital, Southport, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-7601","authenticated-orcid":false,"given":"Hesitha","family":"Abeysundera","sequence":"additional","affiliation":[{"name":"Psychiatry, Gold Coast University Hospital, Southport, Queensland, Australia"},{"name":"Griffith University School of Medicine and Dentistry, Southport, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Jeyaranjan","sequence":"additional","affiliation":[{"name":"Psychiatry, Gold Coast University Hospital, Southport, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"2025082800344734000_16.11.e256796.1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1176\/ajp.2007.164.7.1020","article-title":"Hyperammonaemia due to valproic acid in the psychiatric setting","volume":"164","author":"Carr","year":"2007","journal-title":"AJP"},{"key":"2025082800344734000_16.11.e256796.2","doi-asserted-by":"crossref","unstructured":"Shah S , Wang R , Vieux U . Valproate-induced hyperammonemic encephalopathy: a case report. J Med Case Reports 2020;14. doi:10.1186\/s13256-020-2343-x","DOI":"10.1186\/s13256-020-2343-x"},{"key":"2025082800344734000_16.11.e256796.3","article-title":"Hyperammonemic encephalopathy due to valproic acid and topiramate interaction","volume":"2014","author":"Twilla","year":"2014","journal-title":"Case Rep Psychiatry"},{"key":"2025082800344734000_16.11.e256796.4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0019-5545.42400","article-title":"Valproate monotherapy induced-delirium due to hyperammonaemia \u2013 a report of three adult cases with different types of presentation","volume":"50","author":"Pradeep","year":"2008","journal-title":"Indian J Psychiatry"},{"key":"2025082800344734000_16.11.e256796.5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/24750573.2018.1448133","article-title":"Hyperammonemic encephalopathy without hepatic dysfunction due to treatment with valproate: four cases and a mini review","volume":"28","author":"Din\u00e7er","year":"2018","journal-title":"Psychiatr Clin Psychopharmacol"},{"key":"2025082800344734000_16.11.e256796.6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.genhosppsych.2019.05.005","article-title":"Risk factors for valproic acid-induced hyperammonemia and its association with cognitive functions","volume":"59","author":"Duman","year":"2019","journal-title":"Gen Hosp Psychiatry"},{"key":"2025082800344734000_16.11.e256796.7","article-title":"Valproate-induced hyperammonemic encephalopathy","volume":"9","author":"Farooq","year":"2017","journal-title":"Cureus"},{"key":"2025082800344734000_16.11.e256796.8","doi-asserted-by":"crossref","DOI":"10.1016\/S0924-977X(16)31428-6","article-title":"Valproate induced encephalopathy during treatment of bipolar disorder","volume":"26","author":"Andrade","year":"2016","journal-title":"Eur Neuropsychopharmacol"},{"key":"2025082800344734000_16.11.e256796.9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/ipj.ipj_37_16","article-title":"Valproate induced hyperammonemic encephalopathy treated by haemodialysis","volume":"26","author":"Chauhan","year":"2017","journal-title":"Ind Psychiatry J"},{"key":"2025082800344734000_16.11.e256796.10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s40262-022-01171-w","article-title":"Clinical pharmacokinetic monitoring of free valproic acid levels: a systematic review","volume":"61","author":"Lin","year":"2022","journal-title":"Clin Pharmacokinet"},{"key":"2025082800344734000_16.11.e256796.11","doi-asserted-by":"crossref","unstructured":"Mehta S , Tayabali S , Lachmann R . Valproate-induced hyperammonaemia \u2013 uncovering an underlying inherited metabolic disorder: a case report. J Med Case Reports 2018;12. doi:10.1186\/s13256-018-1666-3","DOI":"10.1186\/s13256-018-1666-3"},{"key":"2025082800344734000_16.11.e256796.12","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200212000-00019"},{"key":"2025082800344734000_16.11.e256796.13","first-page":"6242314","article-title":"Valproic acid induced hyperammonemia in a long time treated patient","volume":"2016","author":"Aiyer","year":"2016","journal-title":"Case Rep Psychiatry"},{"key":"2025082800344734000_16.11.e256796.14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0404.2006.00655.x","article-title":"Valproate induced hyperammonemic encephalopathy","volume":"114","author":"Segura-Bruna","year":"2006","journal-title":"Acta Neurol Scand"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-256796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:34:57Z","timestamp":1756366497000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-256796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,30]]},"published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1136\/bcr-2023-256796"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-256796","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}