{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:10:02Z","timestamp":1756275002089,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,27]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare immune-mediated movement disorder occurring as a paraneoplastic manifestation of neuroblastic tumours (NTs), especially neuroblastoma in infancy. Ganglioneuroma (GN), the benign tumour in the spectrum, is rarely associated with OMAS. We report the case of a child in her second year of life presenting with acute onset of progressive paraplegia and OMAS. MRI showed diffuse and infiltrating left paraspinal mass from T3\u2013T9 levels with differentials of neuroblastoma or ganglioneuroblastoma. Histopathological and immunohistochemistry examination of the excised tumour showed maturing GN. The OMAS was managed with intravenous immunoglobulin and steroids. In the 6-month follow-up, the child has a residual motor weakness with myelomalacia in neuroimaging. The case report substantiates the occurrence of OMAS as paraneoplastic manifestation in NTs, including benign, in children younger than 2 years with a female predilection.<\/jats:p>","DOI":"10.1136\/bcr-2023-256846","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T02:10:14Z","timestamp":1709086214000},"page":"e256846","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Benign paraspinal ganglioneuroma with paraneoplastic opsoclonus myoclonus syndrome"],"prefix":"10.1136","volume":"17","author":[{"given":"Haritha","family":"Prabaharan","sequence":"first","affiliation":[{"name":"Pediatrics, NITTE (Deemed to be University), Mangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suryakala","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Pediatrics, NITTE (Deemed to be University), Mangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-3595","authenticated-orcid":false,"given":"Niharika","family":"Shetty","sequence":"additional","affiliation":[{"name":"Pediatrics, KS Hegde Medical Academy, Mangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-2412","authenticated-orcid":false,"given":"Praveen","family":"Nayak K","sequence":"additional","affiliation":[{"name":"Pediatrics, KS Hegde Medical Academy, Mangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"2025082622482291000_17.2.e256846.1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520110055016"},{"key":"2025082622482291000_17.2.e256846.2","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2017.00468","article-title":"Demographic, clinical, and immunologic features of 389 children with opsoclonus-myoclonus syndrome: a cross-sectional study","volume":"8","author":"Pranzatelli","year":"2017","journal-title":"Front Neurol"},{"key":"2025082622482291000_17.2.e256846.3","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s00415-021-10536-3","article-title":"Opsoclonus-myoclonus-ataxia syndrome in children","volume":"269","author":"Bhatia","year":"2022","journal-title":"J Neurol"},{"key":"2025082622482291000_17.2.e256846.4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0971-5851.64256","article-title":"Ganglioneuroma of the retroperitoneum presenting as a pediatric renal mass","volume":"30","author":"Cyriac","year":"2009","journal-title":"Indian J Med Paediatr Oncol"},{"key":"2025082622482291000_17.2.e256846.5","doi-asserted-by":"crossref","unstructured":"Guven B , Yasar A , Beger B , et al . 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