{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:55:09Z","timestamp":1774328109070,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,3,5]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Overlap syndromes are diseases that meet the criteria of two or more rheumatic diseases. In this case report, a woman in her 20s presented with a constellation of symptoms, including skin thickening, Raynaud\u2019s phenomenon, hypertension, absent pulse in both lower limbs with bilateral renal artery bruit. The antinuclear antibody profile revealed Scl-70 positivity. CT thorax identified early interstitial lung disease, and nailfold capillaroscopy showed severe capillary loss. CT angiogram features were suggestive of Takayasu arteritis. Notably, there have been only four documented cases of systemic sclerosis coexisting with Takayasu arteritis, highlighting the rarity of this overlap syndrome. The diagnosis of overlap syndrome was made after a thorough history recording and clinical examination. In the presence of bilateral renal artery stenosis, managing the scleroderma renal crisis may be challenging . This patient received treatment with mycophenolate mofetil and oral corticosteroids, aiming to address both systemic sclerosis and Takayasu arteritis effectively.<\/jats:p>","DOI":"10.1136\/bcr-2023-256858","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:09:38Z","timestamp":1710338978000},"page":"e256858","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Unusual overlap of systemic sclerosis with Takayasu arteritis"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1004-2282","authenticated-orcid":false,"given":"Anoop","family":"Chithrabhanu","sequence":"first","affiliation":[{"name":"Institute of Rheumatology, Madras Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arul Rajamurugan","family":"Ponniah Subramanian","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Madras Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Madras Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mythili","family":"Seetharaman Varadhan","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Madras Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"2025082709480333000_17.3.e256858.1","article-title":"Takayasu\u2019s arteritis with systemic lupus erythematosus: a rare association","volume":"2015","author":"Bandyopadhyay","year":"2015","journal-title":"Case Rep Rheumatol"},{"key":"2025082709480333000_17.3.e256858.2","first-page":"363","article-title":"Takayasu\u2019s arteritis overlapping with systemic sclerosis","volume":"17","author":"Passiu","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"2025082709480333000_17.3.e256858.3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/s10165-006-0459-5","article-title":"Takayasu arteritis associated with systemic sclerosis","volume":"16","author":"Kocabay","year":"2006","journal-title":"Mod Rheumatol"},{"key":"2025082709480333000_17.3.e256858.4","unstructured":"Yago T , Ota S , Nishinarita M . A case of systemic sclerosis complicated by Takayasu\u2019s arteritis. Ryumachi Rheum 2002:605\u20139."},{"key":"2025082709480333000_17.3.e256858.5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00296-006-0292-3","article-title":"Unilateral weak radial pulse in a patient with systemic sclerosis: Takayasu\u2019s arteritis or Thoracic outlet syndrome","volume":"27","author":"Kim","year":"2007","journal-title":"Rheumatol Int"},{"key":"2025082709480333000_17.3.e256858.6","unstructured":"Roth M . Scleroderma lung study III (SLS III): combining the anti-Fibrotic effects of Pirfenidone (PFD) with mycophenolate (MMF) for treating scleroderma-related interstitial lung disease [Internet]. report no.: Nct03221257 ; 2023. Available: https:\/\/clinicaltrials.gov\/study\/NCT03221257"},{"key":"2025082709480333000_17.3.e256858.7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.5114\/ada.2018.72662","article-title":"Overlap syndromes in systemic sclerosis","volume":"35","author":"Wielosz","year":"2018","journal-title":"Pdia"},{"key":"2025082709480333000_17.3.e256858.8","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170953"},{"key":"2025082709480333000_17.3.e256858.9","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2022.100544","article-title":"Systemic lupus erythematosus and ANCA-associated vasculitis overlap syndrome: A case report","volume":"4","author":"Khil","year":"2022","journal-title":"Kidney Med"},{"key":"2025082709480333000_17.3.e256858.10","first-page":"301","article-title":"Aortoarteritis with systemic lupus erythematosus and secondary antiphospholipid antibody syndrome: a rare association","volume":"54","author":"Gupta","year":"2002","journal-title":"Indian Heart J"},{"key":"2025082709480333000_17.3.e256858.11","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/385938","article-title":"Vasculitis in systemic sclerosis","volume":"2010","author":"Kao","year":"2010","journal-title":"Int J Rheumatol"},{"key":"2025082709480333000_17.3.e256858.12","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.semarthrit.2017.09.014","article-title":"Long-term outcome of 251 patients with Takayasu arteritis on combination immunosuppressant therapy: single centre experience from a large tertiary care teaching hospital in southern India","volume":"47","author":"Goel","year":"2018","journal-title":"Seminars in Arthritis and Rheumatism"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-256858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:48:07Z","timestamp":1756313287000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-256858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,13]]},"published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1136\/bcr-2023-256858"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-256858","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}