{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:04:32Z","timestamp":1756425872804,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,3]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>We report a case of bilateral posterior ischaemic optic neuropathy, which followed vaccination with ChAdOx1 nCoV-19 for COVID-19 prophylaxis. A man in his early 60s was initially assessed for bilateral acute vision loss following 3 days of frontal headaches. The patient denied any other preceding visual concerns or symptoms of giant cell arteritis. The patient received his first dose of the ChAdOx1 nCoV-19 vaccination 10 days before the onset of his symptoms.<\/jats:p>\n               <jats:p>At initial presentation, visual acuity was counting fingers bilaterally. Blood work found normal erythrocyte sedimentation rate (6 mm\/hour) and C reactive protein (&lt;5\u2009mg\/L) as well as a negative infectious and autoimmune serology. He was negative for COVID-19 with PCR testing. Diffusion-weighted MRI showed restricted diffusion along both optic nerves. After 5\u2009months, the patient\u2019s visual acuity remained counting fingers bilaterally with pale optic nerves. Isolated bilateral posterior ischaemic optic neuropathy has not been reported in association with the ChAdOx1 nCoV-19 vaccine.<\/jats:p>","DOI":"10.1136\/bcr-2023-256860","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T12:35:16Z","timestamp":1707914116000},"page":"e256860","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral non-arteritic posterior ischaemic optic neuropathy following COVID-19 vaccination"],"prefix":"10.1136","volume":"17","author":[{"given":"Dominique","family":"Salh","sequence":"first","affiliation":[{"name":"Ophthalmology and Visual Sciences, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlyn","family":"Pinto","sequence":"additional","affiliation":[{"name":"Ophthalmology and Visual Sciences, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Freund","sequence":"additional","affiliation":[{"name":"Clarity Eye Institute, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"2025082804400230000_17.2.e256860.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2007.08.010"},{"key":"2025082804400230000_17.2.e256860.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01199-0"},{"key":"2025082804400230000_17.2.e256860.3","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.3390\/vaccines10101758","article-title":"COVID-19 vaccine-associated optic neuropathy: a systematic review of 45 patients","volume":"10","author":"Elnahry","year":"2022","journal-title":"Vaccines"},{"key":"2025082804400230000_17.2.e256860.4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ajo.2022.02.011","article-title":"COVID-19 vaccination and the eye","volume":"240","author":"Wang","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"2025082804400230000_17.2.e256860.5","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12529","article-title":"Vaccine-induced immune thrombocytopenia and thrombosis (VITT) [published correction appears in Res Pract Thromb Haemost. 2021 Aug 10;5(5):e12585]","volume":"5","author":"Makris","year":"2021","journal-title":"Res Pract Thromb Haemost"},{"key":"2025082804400230000_17.2.e256860.6","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.935095","article-title":"Ischemic optic neuropathy after administration of a SARS-CoV-2 vaccine: a report of 2 cases","volume":"23","author":"Valsero Franco","year":"2022","journal-title":"Am J Case Rep"},{"key":"2025082804400230000_17.2.e256860.7","doi-asserted-by":"crossref","unstructured":"Kumar K , Kohli P , Babu N , et al . Bilateral optic neuropathy after first dose of COVID-19 vaccine. J Neuroophthalmol 2022:1636. doi:10.1097\/WNO.0000000000001636","DOI":"10.1097\/WNO.0000000000001636"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-256860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:40:07Z","timestamp":1756381207000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-256860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,14]]},"published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1136\/bcr-2023-256860"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-256860","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}