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While rare, this case study highlights key principles to the initial diagnostic approach that, in appropriate clinical contexts, should be applied to patients with unlocalised upper GI bleeding. We further perform a complete systematic review of similar cases available in PubMed (36 patients in 24 case reports) to further refine these diagnostic principles.<\/jats:p>","DOI":"10.1136\/bcr-2023-256960","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T12:50:26Z","timestamp":1708519826000},"page":"e256960","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Haemosuccus pancreaticus and seven episodes of recurrent unlocalised upper gastrointestinal bleeding"],"prefix":"10.1136","volume":"17","author":[{"given":"Moustafa","family":"Abdalla","sequence":"first","affiliation":[{"name":"Nuffield Department of Medicine, University of Oxford, Oxford, UK"},{"name":"Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Toronto, Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Fern\u00e1ndez-del","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"2025082704013974000_17.2.e256960.1","doi-asserted-by":"crossref","unstructured":"Sanayei JK , Abdalla M , Ahluwalia M , et al . 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