{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:57Z","timestamp":1756339437766,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,5,17]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Multiple myeloma associated with extramedullary plasmacytoma at initial presentation is rare. We describe a case of a man in his 30s who initially presented with symptoms of spinal cord compression. Further imaging revealed a mediastinal tumour, with a biopsy confirming plasmacytoma. Immunofixation revealed IgA lambda paraprotein. Bone marrow biopsy demonstrated atypical T-cell cytotoxic proliferation and trilineage hypoplasia. The patient was diagnosed with extramedullary plasmacytoma with active IgA multiple myeloma. The patient received mediastinal radiation to the tumour, followed by anti-myeloma therapy. This diagnosis is critical as managing a solitary plasmacytoma drastically differs from an extramedullary plasmacytoma with active multiple myeloma.<\/jats:p>","DOI":"10.1136\/bcr-2023-257026","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T21:10:29Z","timestamp":1717708229000},"page":"e257026","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["IgA multiple myeloma-associated mediastinal spinal plasmacytoma presenting as spinal cord compression"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-7457","authenticated-orcid":false,"given":"Sruti","family":"Prathivadhi-Bhayankaram","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalyn","family":"Marar","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-2946","authenticated-orcid":false,"given":"Samir","family":"Atiya","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mridula","family":"Krishnan","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"2025082704112491000_17.6.e257026.1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1445-5994.1986.tb00010.x","article-title":"Spinal cord compression in multiple myeloma: who gets it?","volume":"16","author":"Woo","year":"1986","journal-title":"Australian and New Zealand Journal of Medicine"},{"key":"2025082704112491000_17.6.e257026.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"2025082704112491000_17.6.e257026.3","first-page":"240","volume-title":"Cancer","volume":"88","author":"Alexiou","year":"2000"},{"key":"2025082704112491000_17.6.e257026.4","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.radcr.2021.04.024","article-title":"Spinal cord compression due to a solitary, bulky Plasmacytoma of posterior Mediastinum","volume":"16","author":"David","year":"2021","journal-title":"Radiology Case Reports"},{"key":"2025082704112491000_17.6.e257026.5","unstructured":"Shukla A , Bansal V , Bhutani R , et al . 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No 4 277 multiple myeloma and Extramedullary Plasmacytoma causing nerve root compression. J Formos Med Assoc 2001;100."},{"key":"2025082704112491000_17.6.e257026.12","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-1-1"},{"key":"2025082704112491000_17.6.e257026.13","doi-asserted-by":"crossref","unstructured":"Chakraborti C , Miller KL . Multiple myeloma presenting as spinal cord compression: a case report. 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