{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:27:59Z","timestamp":1788838079835,"version":"build-2803163510"},"reference-count":12,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,9,24]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Colchicine myopathy typically presents acutely to subacutely with progressive limb weakness. The patients may not be on high doses of colchicine but almost always have acute kidney injury. Dehydration from colchicine-induced diarrhoea is often a precipitating factor. The concomitant neurotoxicity may produce mild sensory complaints. This combination of acute neurological symptoms preceded by diarrhoea prompts the diagnosis of Guillain-Barre syndrome (GBS). The absence of cranial nerve deficits, raised creatine kinase and myotonic discharges on electromyogram may help in differentiating this condition from GBS. We describe a clinical sign, myoedema \u2014 a mounding phenomenon of muscle that is elicited by percussion and resolves when the patient recovers. It aids in the bedside diagnosis of acute colchicine myopathy as well as distinguish it from other more common causes of acute flaccid paralysis. We also discuss the possible mechanism of colchicine toxicity and the mounding phenomenon.<\/jats:p>","DOI":"10.1136\/bcr-2023-257076","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:46:27Z","timestamp":1696941987000},"page":"e257076","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Myoedema: a forgotten sign in acute colchicine myopathy"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1826-5845","authenticated-orcid":false,"given":"Si","family":"Le Tri","sequence":"first","affiliation":[{"name":"Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-388X","authenticated-orcid":false,"given":"Khang","family":"Nguyen Vinh","sequence":"additional","affiliation":[{"name":"Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-5023","authenticated-orcid":false,"given":"Tinh Quang","family":"Dang","sequence":"additional","affiliation":[{"name":"Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-4374","authenticated-orcid":false,"given":"Thirugnanam","family":"Umapathi","sequence":"additional","affiliation":[{"name":"Neurology, National Neuroscience Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"2025082804405987000_16.10.e257076.1","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1056\/NEJM198706183162502","article-title":"Colchicine myopathy and neuropathy","volume":"316","author":"Kuncl","year":"1987","journal-title":"N Engl J Med"},{"key":"2025082804405987000_16.10.e257076.2","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.495348"},{"key":"2025082804405987000_16.10.e257076.3","first-page":"204","article-title":"Colchicine-induced myopathy and neuropathy","volume":"5","author":"Choi","year":"1999","journal-title":"Hong Kong Med J"},{"key":"2025082804405987000_16.10.e257076.4","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.17.1784.52334"},{"key":"2025082804405987000_16.10.e257076.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0682-2"},{"key":"2025082804405987000_16.10.e257076.6","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00553","article-title":"Colchicine myopathy: A case series including muscle MRI and Abcb1 polymorphism data","volume":"10","author":"Gupta","year":"2019","journal-title":"Front Neurol"},{"key":"2025082804405987000_16.10.e257076.7","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2020-002898"},{"key":"2025082804405987000_16.10.e257076.8","unstructured":"Preston D , Shapiro B . Basic Electromyography: analysis of spontaneous activity. In: Electromyography and neuromuscular disorders clinical-electrophysiologic correlations. 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