{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:28:43Z","timestamp":1778902123030,"version":"3.51.4"},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,15]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>We report a middle-childhood girl presented with high-grade fever and headache for 4\u2009days. Following this, the child developed mucocutaneous symptoms. She had a notable family history of autoimmune disease. Tests revealed increased inflammatory markers. On the sixth day of illness, a two-dimensonal echocardiogram showed an enlarged coronary artery, diagnosed as incomplete Kawasaki disease (KD) and treated with IVIG and aspirin.<\/jats:p>\n               <jats:p>Within a week, her younger sibling, an early-childhood girl presented with features of viral prodrome, developed mucocutaneous lesions and subcutaneous oedema of limbs. Her investigations also showed elevated inflammatory markers and echocardiographic changes, diagnosed as incomplete KD.<\/jats:p>\n               <jats:p>The subsequent development of KD in siblings, both showing initial viral symptoms and a family history of autoimmune disease, led to the suspicion of a potential viral trigger. This was confirmed through viral PCR studies for human adenovirus (type 3). These cases highlight an unusual occurrence of KD developing in siblings following acute adenoviral infection.<\/jats:p>","DOI":"10.1136\/bcr-2023-257257","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T02:05:42Z","timestamp":1706148342000},"page":"e257257","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Subsequent development of Kawasaki disease following acute human adenovirus infection among siblings"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-5933","authenticated-orcid":false,"given":"Ashwini","family":"Sankannaavr","sequence":"first","affiliation":[{"name":"Paediatrics, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyashree","family":"Puttalinga","sequence":"additional","affiliation":[{"name":"Paediatrics, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen S","family":"Bagalkot","sequence":"additional","affiliation":[{"name":"Paediatrics, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"2025082707465603000_17.1.e257257.1","first-page":"178","article-title":"Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children","volume":"16","author":"Kawasaki","year":"1967","journal-title":"Arerugi"},{"key":"2025082707465603000_17.1.e257257.2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s13312-020-2033-1","article-title":"Indian academy of pediatrics position paper on Kawasaki disease","volume":"57","author":"Shenoy","year":"2020","journal-title":"Indian Pediatr"},{"key":"2025082707465603000_17.1.e257257.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"2025082707465603000_17.1.e257257.4","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-019-2028-5","article-title":"Kawasaki disease triggered by parvovirus infection: an atypical case report of two siblings","volume":"13","author":"Maggio","year":"2019","journal-title":"J Med Case Rep"},{"key":"2025082707465603000_17.1.e257257.5","doi-asserted-by":"crossref","DOI":"10.7573\/dic.2020-4-1","article-title":"Kawasaki disease in siblings and a review of drug treatment","volume":"9","author":"Loo","year":"2020","journal-title":"Drugs Context"},{"key":"2025082707465603000_17.1.e257257.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2220"},{"key":"2025082707465603000_17.1.e257257.7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113054","article-title":"Kawasaki disease-specific molecules in the sera are linked to microbe-associated molecular patterns in the biofilms","volume":"9","author":"Kusuda","year":"2014","journal-title":"PLoS One"},{"key":"2025082707465603000_17.1.e257257.8","doi-asserted-by":"crossref","DOI":"10.1186\/s12969-017-0169-x","article-title":"Simultaneous development of Kawasaki disease following acute human adenovirus infection in monozygotic twins: a case report","volume":"15","author":"Fukuda","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"2025082707465603000_17.1.e257257.9","unstructured":"Son BF , Newburger JW . Chapter 191: Kawasaki disease. In: Kliegman RM , St. Geme III JW , eds. Nelson Textbook of Pediatrics, 2-Volume Set. 20th edition. 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