{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:37:23Z","timestamp":1772012243731,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,11,16]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Hepatitis A is a common cause of acute infectious hepatitis in children, transmitted through the faeco-oral route. Although mostly self-limiting, cholestasis is a rare but known complication of acute hepatitis A in children. This report presents an adolescent girl who developed cholestatic features following hepatitis A infection and successful treatment with oral steroid therapy. Prolonged cholestasis jaundice (PCJ) is a known manifestation of hepatitis A infection, characterised by prolonged fever, pruritus and jaundice. While the exact mechanisms causing PCJ are not fully understood, immunological-mediated responses could play a role. Treatment options for PCJ are limited, and there is no currently accepted standard of care. Steroids have shown promise in treating PCJ, as observed in this case and a few other reported cases. When other therapies fail to alleviate symptoms, corticosteroids should be considered as a potential treatment option. However, further studies are required to conclusively establish their efficacy.<\/jats:p>","DOI":"10.1136\/bcr-2023-257477","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T13:10:47Z","timestamp":1702127447000},"page":"e257477","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Successful treatment of prolonged cholestasis following hepatitis A infection in a child with oral steroid therapy"],"prefix":"10.1136","volume":"16","author":[{"given":"Ravi","family":"Chirag","sequence":"first","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-5270","authenticated-orcid":false,"given":"Thirunavukkarasu","family":"Arun Babu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"2025082712071971000_16.12.e257477.1","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/0264-410X(92)90533-P","article-title":"Clinical manifestations and diagnosis of hepatitis A virus infection","volume":"10 Suppl 1","author":"Koff","year":"1992","journal-title":"Vaccine"},{"key":"2025082712071971000_16.12.e257477.2","first-page":"134","article-title":"Atypical manifestations of hepatitis A virus infection","volume":"83","author":"Mu\u00f1oz-Mart\u00ednez","year":"2018","journal-title":"Rev Gastroenterol Mex Engl"},{"key":"2025082712071971000_16.12.e257477.3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.5799\/ahinjs.02.2014.04.0161","article-title":"Use of steroids for prolonged cholestasis secondary to acute hepatitis A infection","volume":"4","author":"Pulluk\u00e7u","year":"2014","journal-title":"Jmid"},{"key":"2025082712071971000_16.12.e257477.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70123-9"},{"key":"2025082712071971000_16.12.e257477.5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.14238\/pi41.6.2001.308-10","article-title":"A cholestatic type of hepatitis A in a child","volume":"41","author":"Arief","year":"2001","journal-title":"PI"},{"key":"2025082712071971000_16.12.e257477.6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/0974-777X.100588","article-title":"Prolonged cholestasis following hepatitis A virus infection: revisiting the role of steroids","volume":"4","author":"Saboo","year":"2012","journal-title":"J Glob Infect Dis"},{"key":"2025082712071971000_16.12.e257477.7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00000441-200006000-00014","article-title":"Acute hepatitis A: combination of the relapsing and the cholestatic forms, two rare variants","volume":"319","author":"Rachima","year":"2000","journal-title":"Am J Med Sci"},{"key":"2025082712071971000_16.12.e257477.8","first-page":"485","article-title":"Prolonged cholestasis due to hepatitis A virus infection","volume":"48","author":"Kumar","year":"2011","journal-title":"Indian Pediatr"},{"key":"2025082712071971000_16.12.e257477.9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/ajop.ajop_23_21","article-title":"Spontaneous resolution of prolonged cholestatic jaundice following hepatitis: an infection in a child","volume":"34","author":"Bhowmick","year":"2021","journal-title":"Alex J Pediatr"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-257477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:07:28Z","timestamp":1756321648000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-257477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":9,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,9]]},"published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1136\/bcr-2023-257477"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-257477","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}