{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:47:59Z","timestamp":1758811679170,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,3,14]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Aplasia cutis congenita (ACC) is a group of rare heterogeneous disorders characterised by absent areas of skin at birth. The majority of cases involve the scalp region. ACC limited to one lower limb is extremely rare. We report an usual case of ACC limited to the left thigh of which healing occurred in utero. The case was managed conservatively and the disease course has been favourable with no limitations in limb function and an entirely normal development. Most cases of ACC are self-healing, justifying a conservative approach. This holds further true for ACC limited to one lower limb where the majority of cases reported to date show a favourable disease course with minimal conservative treatment.<\/jats:p>","DOI":"10.1136\/bcr-2023-257572","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T12:40:19Z","timestamp":1713357619000},"page":"e257572","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Aplasia cutis congenita type VII of the lower extremity: a favourable disease course with minimal conservative treatment"],"prefix":"10.1136","volume":"17","author":[{"given":"Kwong Tack","family":"Quach","sequence":"first","affiliation":[{"name":"Dermatology, Haaglanden Medical Center, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien","family":"Wind","sequence":"additional","affiliation":[{"name":"Dermatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"van Mierlo","sequence":"additional","affiliation":[{"name":"Dermatology, Haaglanden Medical Center, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia E","family":"Vos","sequence":"additional","affiliation":[{"name":"Dermatology, Haaglanden Medical Center, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"2025082802294277000_17.4.e257572.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70082-0"},{"key":"2025082802294277000_17.4.e257572.2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/jdv.18690","article-title":"Epidemiology of aplasia cutis congenita: a population\u2010based study in Europe","volume":"37","author":"Coi","year":"2023","journal-title":"Acad Dermatol Venereol"},{"key":"2025082802294277000_17.4.e257572.3","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2002.3915"},{"key":"2025082802294277000_17.4.e257572.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21406.x"},{"key":"2025082802294277000_17.4.e257572.5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.5021\/ad.2008.20.2.70","article-title":"A case of aplasia cutis congenita, type VII","volume":"20","author":"Lee","year":"2008","journal-title":"Ann Dermatol"},{"key":"2025082802294277000_17.4.e257572.6","unstructured":"Brackenrich J , Brown A . Aplasia cutis congenita. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022."},{"key":"2025082802294277000_17.4.e257572.7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003573","article-title":"BMS1 is mutated in aplasia cutis congenita","volume":"9","author":"Marneros","year":"2013","journal-title":"PLoS Genet"},{"key":"2025082802294277000_17.4.e257572.8","first-page":"398","article-title":"Radial dysplasia with localized cutis aplasia congenita","volume":"12","author":"Davidson","year":"2003","journal-title":"J Pediatr Orthop B"},{"key":"2025082802294277000_17.4.e257572.9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1525-1470.2012.01876.x","article-title":"Aplasia cutis congenita of the arm with associated radial dysplasia: case report, review of the literature, and proposed classification","volume":"31","author":"Droubi","year":"2014","journal-title":"Pediatr Dermatol"},{"key":"2025082802294277000_17.4.e257572.10","first-page":"766","article-title":"Frieden\u2019s type 7 aplasia cutis congenita in a premature neonate","volume":"19","author":"Mushtaq","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"2025082802294277000_17.4.e257572.11","article-title":"Congenital cutaneous aplasia of the limbs: a case report","volume":"76","author":"Amaaoune","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"2025082802294277000_17.4.e257572.12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2147\/CCID.S396071","article-title":"Type VII aplasia cutis congenita in neonates related to maternal HBV infection","volume":"16","author":"Li","year":"2023","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2025082802294277000_17.4.e257572.13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/ced.14900","article-title":"A case of aplasia cutis congenita type VII with tibial dysplasia","volume":"47","author":"Doi","year":"2022","journal-title":"Clin Exp Dermatol"},{"key":"2025082802294277000_17.4.e257572.14","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.17.2.123"},{"key":"2025082802294277000_17.4.e257572.15","doi-asserted-by":"crossref","DOI":"10.1186\/s13052-014-0088-0","article-title":"Congenital skin aplasia on the lower limb in a premature infant with ELBW--case report","volume":"40","author":"Paj\u0105k","year":"2014","journal-title":"Ital J Pediatr"},{"key":"2025082802294277000_17.4.e257572.16","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/jamadermatol.2014.111","article-title":"Congenital volkmann syndrome and aplasia cutis of the forearm: a challenging differential diagnosis","volume":"150","author":"Neri","year":"2014","journal-title":"JAMA Dermatol"},{"key":"2025082802294277000_17.4.e257572.17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/jp.2017.142","article-title":"A practical approach to the evaluation and treatment of an infant with aplasia cutis congenita","volume":"38","author":"Humphrey","year":"2018","journal-title":"J Perinatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-257572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:29:49Z","timestamp":1756373389000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-257572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,17]]},"published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1136\/bcr-2023-257572"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-257572","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}