{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:40:10Z","timestamp":1756316410619,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"unspecified","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,7,13]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) remains one of the common metabolic causes of acute pancreatitis in the paediatric population and the third most common cause after alcohol and gallstones in the adult population. We report a case of an early adolescent girl with global developmental delay and moderate cognitive impairment of unknown aetiology who presented with recurrent acute pancreatitis and uncompensated hypovolaemic shock. She was found to have serum triglyceride level of 7877\u2009mg\/dL (reference range&lt;150\u2009mg\/dL) and hyperglycaemia with ketosis (no prior history of diabetes mellitus) that was successfully treated with lipid apheresis. This sometimes is an early modality for treatment in adults; however, it remains a last resort in children, used only for severe cases. A brief literature review on severe HTG-AP and its management is also provided.<\/jats:p>","DOI":"10.1136\/bcr-2023-257587","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T21:25:20Z","timestamp":1723670720000},"page":"e257587","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid apheresis in the management of severe hypertriglyceridaemia in an adolescent girl with global developmental delay"],"prefix":"10.1136","volume":"17","author":[{"given":"Lara","family":"Al-Agailat","sequence":"first","affiliation":[{"name":"Pediatrics, University of Michigan Health - Sparrow, Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Guertin","sequence":"additional","affiliation":[{"name":"Pediatrics - PICU, University of Michigan Health - Sparrow, Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Littlejohn","sequence":"additional","affiliation":[{"name":"Pediatrics and Human Development, Michigan State University and University of Michigan Health - Sparrow, East Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"2025082710122960000_17.8.e257587.1","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.931336","article-title":"Hypertriglyceridemia-induced acute pancreatitis in children: A mini-review","volume":"10","author":"Grisham","year":"2022","journal-title":"Front Pediatr"},{"key":"2025082710122960000_17.8.e257587.2","unstructured":"De La A , Hamilton L , Wilson DP , et al . Management of hospitalized children with severe hypertriglyceridemia. In: Feingold KR , Anawalt B , Blackman MR , eds. Endotext. South Dartmouth, MA: MDText.com, Inc, 2023."},{"key":"2025082710122960000_17.8.e257587.3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.atherosclerosissup.2015.02.017","article-title":"Treatment of primary hypertriglyceridemia states--General approach and the role of extracorporeal methods","volume":"18","author":"Stefanutti","year":"2015","journal-title":"Atheroscler Suppl"},{"key":"2025082710122960000_17.8.e257587.4","doi-asserted-by":"publisher","DOI":"10.1007\/s11789-012-0042-x"},{"key":"2025082710122960000_17.8.e257587.5","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-018-0881-1"},{"key":"2025082710122960000_17.8.e257587.6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.6065\/apem.2040250.125","article-title":"Hypertriglyceridemia with acute pancreatitis in a 14-year-old girl with diabetic ketoacidosis","volume":"27","author":"Park","year":"2022","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"2025082710122960000_17.8.e257587.7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/2042018817739571","article-title":"Role of therapeutic plasma exchange in the treatment of severe hypertriglyceridemia: an experience","volume":"8","author":"Wassay","year":"2017","journal-title":"Ther Adv Endocrinol Metab"},{"key":"2025082710122960000_17.8.e257587.8","first-page":"315","article-title":"Plasmapheresis as an early treatment for severe hypertriglyceridemia, acute pancreatitis, and diabetic ketoacidosis","volume":"7","author":"Kravetz","year":"2021","journal-title":"AACE Clin Case Rep"},{"key":"2025082710122960000_17.8.e257587.9","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-257587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:12:37Z","timestamp":1756314757000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-257587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":9,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8,14]]},"published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1136\/bcr-2023-257587"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-257587","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}