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Right-sided pleural effusion was detected; therefore, he was hospitalised. Based on the observed pleural effusion and biopsy result, the presence of a malignant tumour was excluded; hence, he was diagnosed with benign asbestos pleurisy. He subsequently developed left-sided pleural effusion, masses and lung nodules, and died 9.5 months after the initial examination. A definitive diagnosis of sarcomatoid mesothelioma with rapid systemic progression was established after detailed investigations using autopsy specimens. This rare case of mesothelioma\u2014without <jats:italic>p16<\/jats:italic> deletion (detected using fluorescence in situ hybridisation)\u2014presented differently from the usual sarcomatoid mesothelioma.<\/jats:p>","DOI":"10.1136\/bcr-2023-257618","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T04:35:16Z","timestamp":1707539716000},"page":"e257618","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Detailed clinical course of a patient with rapidly progressing sarcomatoid pleural mesothelioma without p16 deletion with systemic haematogenous metastasis to soft tissues"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-5041","authenticated-orcid":false,"given":"Keiichi","family":"Mizuhashi","sequence":"first","affiliation":[{"name":"Toyama Rosai Hospital, Uozu, 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