{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:40:17Z","timestamp":1756291217378,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,12,28]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>We report a case of vaccine-induced Sweet syndrome in a female patient in her 50s presenting with fevers and a scattered red patchy rash on the lower limbs. Seven days prior, she had received the first dose of AstraZeneca ChAdOx1-S vaccine. A skin biopsy confirmed Sweet syndrome. She did not respond to high doses of prednisolone and required methotrexate therapy to induce remission. This is one of the first reports of Sweet syndrome caused by the ChAdOx1-S vaccine and provides further evidence for vaccine-induced dermatosis. This case demonstrates that methotrexate can induce remission in cases of Sweet syndrome resistant to corticosteroids. This report also describes an approach to the differential diagnosis of patients presenting with a rash, fever and malaise.<\/jats:p>","DOI":"10.1136\/bcr-2023-257635","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:06:01Z","timestamp":1705064761000},"page":"e257635","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Sweet syndrome following the ChAdOx1-S vaccine"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-2657","authenticated-orcid":false,"given":"Olivia","family":"Baker","sequence":"first","affiliation":[{"name":"General Medicine, West Suffolk Hospitals NHS Trust, Bury Saint Edmunds, Suffolk, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun Sen","family":"Chen","sequence":"additional","affiliation":[{"name":"Dermatology, West Suffolk Hospitals NHS Trust, Bury Saint Edmunds, Suffolk, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Kaminska","sequence":"additional","affiliation":[{"name":"Pathology, West Suffolk Hospitals NHS Trust, Bury Saint Edmunds, Suffolk, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"General Medicine, West Suffolk Hospitals NHS Trust, Bury Saint Edmunds, Suffolk, UK"},{"name":"Rheumatology, West Suffolk Hospitals NHS Trust, Bury Saint Edmunds, Suffolk, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"2025082703111472000_17.1.e257635.1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ad.2015.12.001","article-title":"Sweet syndrome: a review and update","volume":"107","author":"Villarreal-Villarreal","year":"2016","journal-title":"Actas Dermosifiliogr"},{"key":"2025082703111472000_17.1.e257635.2","unstructured":"Astra Zeneca . COVID-19 vaccine Astrazeneca. 2021. Available: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/covid-19-vaccine-astrazeneca-product-information-approved-chmp-29-january-2021-pending-endorsement_en.pdf"},{"key":"2025082703111472000_17.1.e257635.3","unstructured":"Teklehaimanot F , Gade A , Rubenstein R . Pityriasis lichenoides et varioliformis acuta (PLEVA). In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2023. 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