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The case highlights the importance of maintaining a wide differential and not being narrowed into a diagnosis or treatment, and given the increasing incidence of human papillomavirus-related cancers, it is important to preserve a high index of suspicion.<\/jats:p>","DOI":"10.1136\/bcr-2023-257679","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T02:10:15Z","timestamp":1709086215000},"page":"e257679","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rare case of p16-positive oropharyngeal cancer metastasis to the orbit"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0463-6442","authenticated-orcid":false,"given":"Chaithanya","family":"Jeganathan","sequence":"first","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-8646","authenticated-orcid":false,"given":"Jian Li","family":"Tan","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia"},{"name":"Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Dhepnorrarat","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"2025082711514828000_17.2.e257679.1","first-page":"869","article-title":"Ocular and orbital metastatic carcinoma","volume":"11","author":"Hutchison","year":"1979","journal-title":"Ann Ophthalmol"},{"key":"2025082711514828000_17.2.e257679.2","doi-asserted-by":"publisher","DOI":"10.1080\/01676830902897470"},{"key":"2025082711514828000_17.2.e257679.3","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S379173"},{"key":"2025082711514828000_17.2.e257679.4","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200106000-00028"},{"key":"2025082711514828000_17.2.e257679.5","first-page":"186","article-title":"Carcinoma of the dura mater. 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