{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:20:53Z","timestamp":1773516053027,"version":"3.50.1"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,2]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>A preterm newborn presented at birth with generalised oedema, disseminated bullous and desquamative exanthema with palmoplantar involvement and hepatomegaly, admitted to the neonatal intensive care unit with severe multisystemic disease, haemodynamic instability and respiratory distress. The mother had a history of treated latent syphilis before pregnancy. Venereal Disease Research Laboratory screening was negative in the first trimester, titre 1:2 in second trimester and 1:32 in the third trimester, a result only available to the medical team at birth. The mother\u2019s rapid plasma reagin (RPR) titre was 1:64 at birth. The newbon\u2019s RPR titre was 1:256, confirming the diagnosis of early congenital syphilis. The newborn was treated with aqueous penicillin G, with clinical and laboratorial progressive recovery. Congenital syphilis is a preventable disease, but despite prenatal screening programmes, it remains a significant public health issue worldwide with high morbidity and mortality.<\/jats:p>","DOI":"10.1136\/bcr-2023-257694","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T02:30:21Z","timestamp":1705458621000},"page":"e257694","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Congenital syphilis: the re-emergence of a forgotten disease"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-2267","authenticated-orcid":false,"given":"Ana Isabel","family":"Foles","sequence":"first","affiliation":[{"name":"Neonatology, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Eiras Dias","sequence":"additional","affiliation":[{"name":"Neonatology, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Neonatology, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Mar\u00e7al","sequence":"additional","affiliation":[{"name":"Neonatology, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"2025082709513202000_17.1.e257694.1","unstructured":"World Health Organization . Global health sector - strategy on sexually transmitted infections 2016-2021 - towards ending Stis; 2016."},{"key":"2025082709513202000_17.1.e257694.2","unstructured":"World Health Organization . Global progress report on HIV, viral hepatitis and sexually transmitted infections - accountability for the global health sector strategies 2016\u20132021: actions for impact; 2021."},{"key":"2025082709513202000_17.1.e257694.3","unstructured":"Walensky RP , Jernigan DB , Bunnell R , et al . Sexually transmitted infections treatment guidelines, 2021. Morbidity and mortality weekly report sexually transmitted infections (centers for disease control and prevention); 2021."},{"key":"2025082709513202000_17.1.e257694.4","unstructured":"Centers for Disease Control and Prevention . Sexually transmitted disease surveillance, 2021. Atlanta GA; 2021."},{"key":"2025082709513202000_17.1.e257694.5","unstructured":"European Centre for Disease Prevention and Control . Annual Epidemiological report congenital Syphilis 2019. Stockholm; 2022."},{"key":"2025082709513202000_17.1.e257694.6","unstructured":"Kimball A , Torrone E , Miele K , et al . Morbidity and mortality weekly report missed opportunities for prevention of congenital Syphilis-United States, 2018; 2018. Available: https:\/\/www.cdc.gov\/mmwr\/mmwr_continuingEducation.html"},{"key":"2025082709513202000_17.1.e257694.7","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1056\/NEJMc2111103","article-title":"High congenital Syphilis case counts among U.S. infants born in 2020","volume":"385","author":"Bowen","year":"2021","journal-title":"N Engl J Med"},{"key":"2025082709513202000_17.1.e257694.8","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-318841"},{"key":"2025082709513202000_17.1.e257694.9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ajog.2015.10.007","article-title":"Congenital Syphilis: trends in mortality and morbidity in the United States, 1999 through 2013","volume":"214","author":"Su","year":"2016","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2025082709513202000_17.1.e257694.10","article-title":"Congenital Syphilis\u2014an illustrative review","volume":"10","author":"Sankaran","year":"2023","journal-title":"Children (Basel)"},{"key":"2025082709513202000_17.1.e257694.11","unstructured":"American Academy of Pediatrics . Committee on infectious diseases. In: Kimberlin DW , Barnett ED , Elizabeth D , et al , eds. Red book: 2021-2024 report of the Committee on Infectious Diseases. American Academy of Pediatrics, 2021: 1146."},{"key":"2025082709513202000_17.1.e257694.12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00431-022-04703-5","article-title":"Congenital Syphilis in the twenty-first century: an area-based study","volume":"182","author":"Salom\u00e8","year":"2023","journal-title":"Eur J Pediatr"},{"key":"2025082709513202000_17.1.e257694.13","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1016\/S1473-3099(20)30268-1","article-title":"Congenital syphilis, the great imitator\u2014case report and review","volume":"20","author":"Keuning","year":"2020","journal-title":"The Lancet Infectious Diseases"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-257694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:51:38Z","timestamp":1756313498000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-257694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,16]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1136\/bcr-2023-257694"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-257694","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}