{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:55:18Z","timestamp":1776790518268,"version":"3.51.2"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,3]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>We present a case of an ectopic breast adenocarcinoma of the vulva with metastatic local recurrence and a total follow-up period of 19 years, the longest documented in the literature to our knowledge. Following surgical excision, radiation therapy and hormonal treatment after the recurrence, the patient has remained disease free. This case demonstrates the potential for malignant transformation in accessory breast tissue and highlights the importance of close surveillance and regular physical examinations in patients with a history of ectopic breast malignancy.<\/jats:p>","DOI":"10.1136\/bcr-2023-257791","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T07:55:36Z","timestamp":1708156536000},"page":"e257791","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent ectopic primary breast adenocarcinoma of the vulva with a 19-year follow-up period"],"prefix":"10.1136","volume":"17","author":[{"given":"Mirelys","family":"Barrios","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7761-2181","authenticated-orcid":false,"given":"Nathalie E","family":"Perez","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence M","family":"Briski","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric","family":"Pluguez-Turull","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"2025082711055028000_17.2.e257791.1","first-page":"1389","article-title":"Ectopic breast cancer of the axilla","volume":"129","author":"Amsler","year":"2002","journal-title":"Ann Dermatol Venereol"},{"key":"2025082711055028000_17.2.e257791.2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-7404(94)90032-9"},{"key":"2025082711055028000_17.2.e257791.3","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-021-02998-w","article-title":"Primary ectopic axillary breast cancer: a case series","volume":"15","author":"Sghaier","year":"2021","journal-title":"J Med Case Rep"},{"key":"2025082711055028000_17.2.e257791.4","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5269"},{"key":"2025082711055028000_17.2.e257791.5","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1016\/j.clbc.2017.06.004","article-title":"A rare presentation of primary breast carcinoma in the vulva: a case report and literature review","volume":"18","author":"Lopes","year":"2018","journal-title":"Clin Breast Cancer"},{"key":"2025082711055028000_17.2.e257791.6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4048\/jbc.2014.17.4.393","article-title":"Ductal carcinoma arising from ectopic breast tissue following microcalcification observed on screening mammography: a case report and review of the literature","volume":"17","author":"Lee","year":"2014","journal-title":"J Breast Cancer"},{"key":"2025082711055028000_17.2.e257791.7","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31823b3bc6"},{"key":"2025082711055028000_17.2.e257791.8","doi-asserted-by":"crossref","DOI":"10.7812\/TPP\/19.084","article-title":"Primary breast carcinoma of the vulva metastatic to lymph nodes and bones: a case report and literature review","volume":"24","author":"Ananthula","year":"2020","journal-title":"Perm J"},{"key":"2025082711055028000_17.2.e257791.9","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2214\/AJR.13.10930","article-title":"The ABCs of accessory breast tissue: basic information every radiologist should know","volume":"202","author":"DeFilippis","year":"2014","journal-title":"AJR Am J Roentgenol"},{"key":"2025082711055028000_17.2.e257791.10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3346\/jkms.2001.16.4.519","article-title":"Carcinoma originating from aberrant breast tissue of the right upper anterior chest wall : a case report","volume":"16","author":"Rho","year":"2001","journal-title":"J Korean Med Sci"},{"key":"2025082711055028000_17.2.e257791.11","unstructured":"NIH National Cancer Institute . Age and cancer risk. n.d. Available: https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/age"},{"key":"2025082711055028000_17.2.e257791.12","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.5858\/2002-126-1216-MAOEBT","article-title":"Mucinous adenocarcinoma of ectopic breast tissue of the vulva","volume":"126","author":"Chung-Park","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"2025082711055028000_17.2.e257791.13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/ijgo.14474","article-title":"Vulvar ductal carcinoma in situ as a manifestation of ectopic breast tissue","volume":"160","author":"Sandak","year":"2023","journal-title":"Int J Gynaecol Obstet"},{"key":"2025082711055028000_17.2.e257791.14","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1111\/jog.13778","article-title":"Primary breast cancer of the vulva: a case report and literature review","volume":"44","author":"Al-Mansouri","year":"2018","journal-title":"J Obstet Gynaecol Res"},{"key":"2025082711055028000_17.2.e257791.15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/01443615.2019.1623182","article-title":"Primary ectopic lobular breast cancer of the vulva: case report and review of literature","volume":"40","author":"Matak","year":"2020","journal-title":"J Obstet Gynaecol"},{"key":"2025082711055028000_17.2.e257791.16","doi-asserted-by":"crossref","DOI":"10.1186\/s40792-017-0343-x","article-title":"Primary ectopic breast cancer of the vulva, treated with local excision of the vulva and sentinel lymph node biopsy: a case report","volume":"3","author":"Ishigaki","year":"2017","journal-title":"Surg Case Rep"},{"key":"2025082711055028000_17.2.e257791.17","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2006.n.041"},{"key":"2025082711055028000_17.2.e257791.18","article-title":"Primary breast adenocarcinoma in ectopic breast tissue in the vulva","volume":"2013","author":"McMaster","year":"2013","journal-title":"Case Rep Obstet Gynecol"},{"key":"2025082711055028000_17.2.e257791.19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5306\/wjco.v6.i2.16","article-title":"Sentinel lymph node mapping of a breast cancer of the vulva: case report and literature review","volume":"6","author":"Cripe","year":"2015","journal-title":"World J Clin Oncol"},{"key":"2025082711055028000_17.2.e257791.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00817.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-257791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:06:02Z","timestamp":1756317962000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-257791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,17]]},"published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1136\/bcr-2023-257791"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-257791","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}