{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:56Z","timestamp":1756339556647,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,26]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>A term baby presented with cholestatic jaundice since birth. She was diagnosed as gestational alloimmune liver disease-neonatal haemochromatosis (GALD-NH) on evaluation. The baby received intravenous immunoglobulin (IVIG) and recovered gradually from the illness. She was also diagnosed with alpha thalassaemia during the course of evaluation, confirmed by genetic testing. NH is a very rare disorder that results in fetal loss or neonatal death due to liver failure. NH is now known to be a phenotypic expression of GALD. Worldwide, NH is seen in less than one in a million pregnancies. The mortality rate of GALD has traditionally been around 80% with almost all babies needing liver transplantation, with advent of maternal and neonatal IVIG treatment, this has reduced significantly. There is no reported case of GALD-NH treated successfully with IVIG from India. Here, we report an interesting case of GALD-NH with alpha thalassaemia.<\/jats:p>","DOI":"10.1136\/bcr-2023-257950","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T13:00:45Z","timestamp":1711026045000},"page":"e257950","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational alloimmune liver disease with alpha thalassaemia in a neonate"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-1751","authenticated-orcid":false,"given":"Nishant","family":"Banait","sequence":"first","affiliation":[{"name":"Neonatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Vamshi","family":"Varanasi","sequence":"additional","affiliation":[{"name":"Neonatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abinash","family":"Nayak","sequence":"additional","affiliation":[{"name":"Neonatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kushal","family":"Talukder","sequence":"additional","affiliation":[{"name":"Neonatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"2025082711094385000_17.3.e257950.1","unstructured":"Neonatal Hemochromatosis - Stanford medicine children\u2019s health. 2023. Available: https:\/\/www.stanfordchildrens.org\/en\/service\/fetal-and-pregnancy-health\/conditions\/neonatal-hemochromatosis [Accessed 22 Jul 2023]."},{"key":"2025082711094385000_17.3.e257950.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-139468"},{"key":"2025082711094385000_17.3.e257950.3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/1742271X221091710","article-title":"Case report of fetal liver cirrhosis due to gestational alloimmune liver disease in a primigravida female, in the northeast region of India","volume":"31","author":"Maheshwari","year":"2023","journal-title":"Ultrasound"},{"key":"2025082711094385000_17.3.e257950.4","doi-asserted-by":"crossref","unstructured":"Tolani D , Ahmed J , Mullanfiroze K , et al . Neonatal hemochromatosis - a fulminant cause of neonatal cholestasis. Pediatric Oncall 2022;19. doi:10.7199\/ped.oncall.2022.34","DOI":"10.7199\/ped.oncall.2022.34"},{"key":"2025082711094385000_17.3.e257950.5","doi-asserted-by":"crossref","first-page":"103347","DOI":"10.1016\/j.transci.2021.103347","article-title":"Gestational alloimmune liver disease treated with exchange transfusion and intravenous immunoglobulin: a case study","volume":"61","author":"Park","year":"2022","journal-title":"Transfus Apher Sci"},{"key":"2025082711094385000_17.3.e257950.6","unstructured":"Isa HM , Mohamed AM . Neonatal Hemochromatosis. Case Series from Bahrain Saudi Medical Journal 2013:1274\u201380."},{"key":"2025082711094385000_17.3.e257950.7","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/hep.31109","article-title":"Liver diseases in the perinatal period: interactions between mother and infant","volume":"71","author":"Ibrahim","year":"2020","journal-title":"Hepatology"},{"key":"2025082711094385000_17.3.e257950.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2013.10.004"},{"key":"2025082711094385000_17.3.e257950.9","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.680730","article-title":"Efficacy of intravenous immunoglobulin\/exchange transfusion therapy on gestational alloimmune liver disease","volume":"9","author":"Yeh","year":"2021","journal-title":"Front Pediatr"},{"key":"2025082711094385000_17.3.e257950.10","unstructured":"Hemoglobin H disease - an overview. 2023. Available: https:\/\/www.sciencedirect.com\/topics\/nursing-and-health-professions\/hemoglobin-h-disease [Accessed 29 Jul 2023]."},{"key":"2025082711094385000_17.3.e257950.11","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2023.1077304","article-title":"GALD: new diagnostic tip for early diagnosis - a case report and literature review","volume":"5","author":"Zermano","year":"2023","journal-title":"Front Reprod Health"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-257950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:09:55Z","timestamp":1756318195000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-257950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,21]]},"published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1136\/bcr-2023-257950"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-257950","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}