{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:15:45Z","timestamp":1787166945226,"version":"build-2736575974"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,4,9]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described chronic inflammatory central nervous system disease. This case report describes a young female patient presenting with weakness in bilateral upper and lower limbs and tinnitus for 2\u2009months. A neurological examination revealed signs of brainstem and cerebellar involvement. MRI brain showed characteristic features of CLIPPERS, with punctate and nodular enhancement in the pons and cerebellum. Differential diagnoses were systematically considered and excluded. The patient showed significant clinical and radiological improvement with steroid therapy. No clinical or radiological red flags occurred during the follow-up. This case underscores the critical role of integrating clinical and radiological findings to effectively diagnose and manage CLIPPERS. It emphasises the importance of ruling out alternative diagnoses through a thorough evaluation.<\/jats:p>","DOI":"10.1136\/bcr-2023-258067","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T13:27:18Z","timestamp":1713274038000},"page":"e258067","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicoradiological features of probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome"],"prefix":"10.1136","volume":"17","author":[{"given":"Deepa Susan","family":"John","sequence":"first","affiliation":[{"name":"Department of Radiology, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5908-6385","authenticated-orcid":false,"given":"Shreyas Reddy","family":"Kankara","sequence":"additional","affiliation":[{"name":"Department of Radiology, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunitha","family":"Palasamudram Kumaran","sequence":"additional","affiliation":[{"name":"Department of Radiology, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan Sarfaraz","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Radiology, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"2025082709242567000_17.4.e258067.1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq164"},{"key":"2025082709242567000_17.4.e258067.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318957"},{"key":"2025082709242567000_17.4.e258067.3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301054"},{"key":"2025082709242567000_17.4.e258067.4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/cei.12204","article-title":"CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders","volume":"175","author":"Dudesek","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"2025082709242567000_17.4.e258067.5","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.2.1820289"},{"key":"2025082709242567000_17.4.e258067.6","doi-asserted-by":"crossref","DOI":"10.1177\/1756286418785071","article-title":"Primary angiitis of the central nervous system: diagnosis and treatment","volume":"11","author":"Beuker","year":"2018","journal-title":"Ther Adv Neurol Disord"},{"key":"2025082709242567000_17.4.e258067.7","doi-asserted-by":"publisher","DOI":"10.1136\/pn-2023-003875"},{"key":"2025082709242567000_17.4.e258067.8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24881"},{"key":"2025082709242567000_17.4.e258067.9","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1148\/radiol.14131355","article-title":"Case 212: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids","volume":"273","author":"Bag","year":"2014","journal-title":"Radiology"},{"key":"2025082709242567000_17.4.e258067.10","doi-asserted-by":"crossref","unstructured":"Taieb G , Duflos C , Renard D , et al . Long-term outcomes of CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) in a consecutive series of 12 patients. 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