{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:02:52Z","timestamp":1785603772796,"version":"3.56.0"},"reference-count":9,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,5]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Hypocalcaemia is a common cause of neonatal seizures. Here, we present a breastfed neonate with smooth perinatal transition and no family history of seizures presenting at 3 weeks with recurrent multifocal clonic seizures. On evaluation, the neonate was found to have low iCa and total calcium. 25-hydroxy vitamin D (25(OH)D) level was low and intact parathyroid hormone (iPTH) was inappropriately normal. The maternal evaluation revealed high calcium and low phosphate levels. iPTH was very high and 25(OH)D was very low in the mother. Sestamibi scan showed a left inferior parathyroid adenoma in the mother. Maternal primary hyperparathyroidism causing hypercalcaemia can suppress parathyroid activity in the fetus, resulting in inappropriate parathyroid response to hypocalcaemia after birth causing recurrent hypocalcaemic seizures. So neonatal hypocalcaemic seizures need careful evaluation of the neonate and the mother at times and can help both mother and neonate.<\/jats:p>","DOI":"10.1136\/bcr-2023-258134","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T12:01:18Z","timestamp":1707998478000},"page":"e258134","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal hypocalcaemic seizures unmasking asymptomatic maternal primary hyperparathyroidism"],"prefix":"10.1136","volume":"17","author":[{"given":"Ramandeep","family":"Kaur","sequence":"first","affiliation":[{"name":"Neonatology, All India Institute of Medical Science, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8456-1133","authenticated-orcid":false,"given":"Sushil Kumar","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Neonatology, All India Institute of Medical Science, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunkumarendu","family":"Singh","sequence":"additional","affiliation":[{"name":"Neonatology, All India Institute of Medical Science, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Neonatology, All India Institute of Medical Science, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"2025082623334787000_17.2.e258134.1","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1210\/jc.2015-1110","article-title":"Pregnancy Outcomes in Women With Primary Hyperparathyroidism","volume":"100","author":"Hirsch","year":"2015","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"2025082623334787000_17.2.e258134.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-006-0748-1"},{"key":"2025082623334787000_17.2.e258134.3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00431-007-0528-6","article-title":"Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism","volume":"167","author":"Poomthavorn","year":"2008","journal-title":"Eur J Pediatr"},{"key":"2025082623334787000_17.2.e258134.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-002-0316-5"},{"key":"2025082623334787000_17.2.e258134.5","first-page":"905","article-title":"Evaluation of urinary calcium\/creatinine ratio in premature and full-term newborn infants","volume":"48","author":"Lavocat","year":"1993","journal-title":"Pediatrie"},{"key":"2025082623334787000_17.2.e258134.6","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1210\/clinem\/dgaa111","article-title":"Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)","volume":"105","author":"Dharmaraj","year":"2020","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"2025082623334787000_17.2.e258134.7","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4318075","article-title":"Clinical Approach to Hypocalcemia in Newborn Period and Infancy: Who Should Be Treated?","volume":"2019","author":"Vuralli","year":"2019","journal-title":"Int J Pediatr"},{"key":"2025082623334787000_17.2.e258134.8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.32677\/IJCH.2018.v05.i11.006","article-title":"Study of incidence of hypocalcemia in infants admitted with seizures in a tertiary care hospital","volume":"5","author":"Bande","year":"2018","journal-title":"IJCH"},{"key":"2025082623334787000_17.2.e258134.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80509-6"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-258134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:33:56Z","timestamp":1756276436000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-258134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,15]]},"published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1136\/bcr-2023-258134"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-258134","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}