{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:05:15Z","timestamp":1793286315970,"version":"4.5.0"},"reference-count":8,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,4,2]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>A man in his 60s presented with a widespread erythematous rash and associated chills, paraesthesia and haematuria. He had recently commenced naproxen\/esomeprazole. Blood tests showed hypereosinophilia (0.73\u00d710<jats:sup>9<\/jats:sup>\/L) and moderate acute kidney injury. Histology revealed parakeratosis, mild spongiosis with eosinophils. He developed acute coronary syndrome with rapid atrial fibrillation. Coronary angiogram was non-obstructive. Cardiac MRI (CMR) revealed acute myocarditis secondary to Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Naproxen\/esomeprazole was discontinued, and he was supported with oral corticosteroids. A repeat CMR 3\u2009months later showed resolution of myocarditis. Naproxen\/esomeprazole is not a common offending drug. DRESS is a rare drug-induced hypersensitivity reaction with a mortality rate of 10%. The objective of this case report is to highlight the significant but rare cardiac complications that can ensue from DRESS, which warrant prompt recognition and withdrawal of the causative drug.<\/jats:p>","DOI":"10.1136\/bcr-2023-258187","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T22:40:12Z","timestamp":1712702412000},"page":"e258187","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Severe DRESS with myocarditis secondary to naproxen\/esomeprazole"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-6881","authenticated-orcid":false,"given":"Sarah","family":"O'Mahony","sequence":"first","affiliation":[{"name":"Dermatology, Tallaght University Hospital, Dublin, Ireland"},{"name":"Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Marie","family":"Tobin","sequence":"additional","affiliation":[{"name":"Dermatology, Tallaght University Hospital, Dublin, Ireland"},{"name":"Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Mary","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Geriatric Medicine, Midlands Regional Hospital Tullamore, Tullamore, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"2025082709532970000_17.4.e258187.1","unstructured":"UpToDate . Drug reaction with eosinophilia and systemic symptoms (dress) Massachusetts UpToDate Inc, 2023. 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