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He had significant ongoing issues with visceral hyperalgesia that was refractory to a wide range of pharmacological treatments and required admission to the intensive care unit on multiple occasions, and consultations with international experts in Pitt-Hopkins syndrome and pain specialists. An individualised pain plan was created and adjusted over time, with eventual good effect, and he was transferred back to his regional hospital and subsequently discharged home.<\/jats:p>","DOI":"10.1136\/bcr-2023-258257","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T12:55:46Z","timestamp":1708347346000},"page":"e258257","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Complex visceral hyperalgesia in an adolescent with Pitt-Hopkins syndrome"],"prefix":"10.1136","volume":"17","author":[{"given":"Laura","family":"Reaney","sequence":"first","affiliation":[{"name":"General Paediatrics, Children's Health Ireland at Crumlin, Dublin 12, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aedin","family":"Collins","sequence":"additional","affiliation":[{"name":"CHI at Tallaght, Dublin, Dublin 24, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"2025082710361028000_17.2.e258257.1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13506"},{"key":"2025082710361028000_17.2.e258257.2","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.32","article-title":"Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription","volume":"45","author":"Sweatt","year":"2013","journal-title":"Exp Mol Med"},{"key":"2025082710361028000_17.2.e258257.3","unstructured":"Dean L . 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