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After review of 260 cases in the literature we determined a disease-specific survival of 33.1%. Combined chemoradiotherapy is currently the recommended first-line treatment option.<\/jats:p>","DOI":"10.1136\/bcr-2023-258269","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T12:45:54Z","timestamp":1706013954000},"page":"e258269","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic challenges in small cell carcinoma of the larynx"],"prefix":"10.1136","volume":"17","author":[{"given":"Kimberly","family":"D'Mello","sequence":"first","affiliation":[{"name":"Otolaryngology, Head & Neck Surgery, The Royal Melbourne Hospital City Campus, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jevan","family":"Cevik","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head & Neck Surgery, The Royal Melbourne Hospital City Campus, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-6214","authenticated-orcid":false,"given":"Daniel Jun Yi","family":"Wong","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head & Neck Surgery, The Royal Melbourne Hospital City Campus, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Hart","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head & Neck Surgery, The Royal Melbourne Hospital City Campus, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"2025082709241194000_17.1.e258269.1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hed.20797","article-title":"Primary and secondary small cell neuroendocrine carcinoma of the Larynx: a review","volume":"30","author":"Ferlito","year":"2008","journal-title":"Head Neck"},{"key":"2025082709241194000_17.1.e258269.2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100218"},{"key":"2025082709241194000_17.1.e258269.3","doi-asserted-by":"publisher","DOI":"10.1177\/000348947408300214"},{"key":"2025082709241194000_17.1.e258269.4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12105-017-0788-z","article-title":"Update from the 4th edition of the World Health Organization classification of head and neck tumours: what is new in the 2017 WHO blue book for tumours of the hypopharynx, larynx, trachea and parapharyngeal space","volume":"11","author":"Gale","year":"2017","journal-title":"Head Neck Pathol"},{"key":"2025082709241194000_17.1.e258269.5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000072249","article-title":"Small cell neuroendocrine carcinoma of the Larynx: a preventable and frustrating disease with a highly aggressive lethal behavior","volume":"65","author":"Ferlito","year":"2003","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"2025082709241194000_17.1.e258269.6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23666"},{"key":"2025082709241194000_17.1.e258269.7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1017\/S0022215118000968","article-title":"How phenotype guides management of the neuroendocrine carcinomas of the larynx","volume":"132","author":"L\u00f3pez","year":"2018","journal-title":"J Laryngol Otol"},{"key":"2025082709241194000_17.1.e258269.8","doi-asserted-by":"crossref","unstructured":"Niermann KJ , Gilbert J , Mannion K , et al . 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