{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:42:37Z","timestamp":1756381357389,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,11,18]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>We present a case of advanced well-differentiated liposarcoma transforming to dedifferentiated liposarcoma in the bone marrow.<\/jats:p>\n               <jats:p>Our patient presented with 5 weeks of worsening flank pain. He was found to have profound leukocytosis, thrombocytopenia, and normocytic anemia. Imaging showed a dominant retrocaval mass concerning for viable disease. Bone marrow biopsy revealed dedifferentiated liposarcoma with heterologous rhabdomyosarcomatous differentiation. He underwent 3 cycles of eribulin and subsequently developed complications of his increasingly aggressive liposarcoma. He was transitioned to hospice care and died 3 months after initial bone marrow biopsy. While exceedingly rare, it is possible for liposarcoma to metastasize to the bone marrow and cause rapid progression to death. In patients with high-grade liposarcoma, new cytopenia, leukocytosis, elevated granulocyte colony stimulating factor, and\/or leukoerythroblasosis on peripheral smear should prompt bone marrow biopsy for early detection of this rare disease entity.<\/jats:p>","DOI":"10.1136\/bcr-2023-258298","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T13:10:34Z","timestamp":1702127434000},"page":"e258298","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Dedifferentiated liposarcoma with heterologous rhabdomyosarcomatous differentiation in the bone marrow"],"prefix":"10.1136","volume":"16","author":[{"given":"Spencer","family":"Scott","sequence":"first","affiliation":[{"name":"The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laleh","family":"Hakima","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-858X","authenticated-orcid":false,"given":"Evan","family":"Raff","sequence":"additional","affiliation":[{"name":"Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"2025082804250939000_16.12.e258298.1","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-213"},{"key":"2025082804250939000_16.12.e258298.2","unstructured":"Key statistics for soft tissue sarcomas American Cancer Society . 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