{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:50Z","timestamp":1756339370700,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,3,21]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Involvement of the cervix with acute lymphoblastic leukaemia (ALL) is extremely rare. In this case report, we discuss an unmarried woman in her early 20s, who presented in the emergency with lower abdominal pain and irregular vaginal bleeding for 1\u2009month. Clinical examination and imaging revealed a large cervical mass probably neoplastic with obstructive uropathy. On evaluation, she was diagnosed incidentally with CALLA-positive precursor B cell ALL in peripheral blood flow cytometry. Involvement of B cell ALL in cervical mass was confirmed by histopathological examination of cervical biopsy and immunohistochemistry markers. Her history was not suggestive of signs and symptoms pertaining to leukaemia. Literature is sparse with only a few cases reporting cervical leukaemic infiltration. The present case report is a rarest case where the primary\/initial presentation of precursor B cell ALL was seen with cervical involvement and obstructive uropathy mimicking characteristics of advanced cervical malignancy.<\/jats:p>","DOI":"10.1136\/bcr-2023-258313","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T01:55:19Z","timestamp":1712109319000},"page":"e258313","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Aggressive precursor B cell ALL of cervix with obstructive uropathy"],"prefix":"10.1136","volume":"17","author":[{"given":"Anupama","family":"Bahadur","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3359-2239","authenticated-orcid":false,"given":"Rajlaxmi","family":"Mundhra","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Gill","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Singh","sequence":"additional","affiliation":[{"name":"Pathology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"2025082700483041000_17.4.e258313.1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1053\/adpa.2002.32381","article-title":"Precursor T-cell acute lymphoblastic leukemia\/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix","volume":"6","author":"Lyman","year":"2002","journal-title":"Ann Diagn Pathol"},{"key":"2025082700483041000_17.4.e258313.2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PGP.0b013e31825bd828","article-title":"Recurrent precursor-B acute lymphoblastic leukemia presenting as a cervical malignancy","volume":"32","author":"Kazi","year":"2013","journal-title":"Int J Gynecol Pathol"},{"doi-asserted-by":"publisher","key":"2025082700483041000_17.4.e258313.3","DOI":"10.1056\/NEJM200004063421402"},{"key":"2025082700483041000_17.4.e258313.4","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2019-127985","article-title":"Encouraging results with ALL IC-BFM 2009 protocol therapy in pediatric acute lymphoblastic leukemia\/lymphoma in resource-limited setting: a single-center study from India","volume":"134","author":"Nath","year":"2019","journal-title":"Blood"},{"key":"2025082700483041000_17.4.e258313.5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00043426-199608000-00017","article-title":"Childhood acute lymphoblastic leukemia relapse in the uterine cervix","volume":"18","author":"Tsuruchi","year":"1996","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025082700483041000_17.4.e258313.6","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/modpathol.3880442","article-title":"Ovarian non-Hodgkin\u2019s lymphoma: a clinicopathologic study of eight primary cases","volume":"14","author":"Vang","year":"2001","journal-title":"Mod Pathol"},{"key":"2025082700483041000_17.4.e258313.7","doi-asserted-by":"crossref","first-page":"882","DOI":"10.12659\/MSM.892807","article-title":"The prognostic role of Ki67\/MIB-1 in cervical cancer: a systematic review with meta-analysis","volume":"21","author":"Pan","year":"2015","journal-title":"Med Sci Monit"},{"key":"2025082700483041000_17.4.e258313.8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.5858\/2008-132-462-ALIASD","article-title":"Acute leukemia immunohistochemistry: a systematic diagnostic approach","volume":"132","author":"Olsen","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"2025082700483041000_17.4.e258313.9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4103\/2278-0513.152745","article-title":"Acute lymphoblastic leukemia presenting with a uterine cervical mass","volume":"4","author":"Geetha","year":"2015","journal-title":"Clin Cancer Investig J"},{"key":"2025082700483041000_17.4.e258313.10","first-page":"249","article-title":"Unusual extramedullary relapses in a case of common B-cell acute lymphoblastic leukemia. 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