{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:57:23Z","timestamp":1759960643026,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,22]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Pseudohypoparathyroidism (PHP) is a rare genetic disorder characterised by a non-functioning PTH. Usually, the diagnosis is made following (symptomatic) hypocalcaemia. We describe a case in which epileptic seizures and abnormalities in dental development were the main clinical manifestation of PHP type 1B. This case demonstrates the importance of screening for hypocalcaemia in patients with <jats:italic>de novo<\/jats:italic> epileptic seizures. In addition, antiepileptic medications themselves may interfere with calcium-phosphate metabolism, causing or aggravating a hypocalcaemia as well. By correcting the calcium level, a resolution of these symptoms could be obtained.<\/jats:p>","DOI":"10.1136\/bcr-2023-258403","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T12:00:44Z","timestamp":1709208044000},"page":"e258403","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Epileptic seizures and abnormal tooth development as primary presentation of pseudohypoparathyroidism type 1B"],"prefix":"10.1136","volume":"17","author":[{"given":"Anne-Marie","family":"Van der Biest","sequence":"first","affiliation":[{"name":"Endocrinology, UZ Brussel, Brussel, Belgium"},{"name":"Endocrinology, AZ Glorieux, Ronse, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"J\u00fcppner","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Andreescu","sequence":"additional","affiliation":[{"name":"Endocrinology, UZ Brussel, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Bravenboer","sequence":"additional","affiliation":[{"name":"Endocrinology, UZ Brussel, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"2025082803302897000_17.2.e258403.1","doi-asserted-by":"crossref","first-page":"e3005","DOI":"10.1210\/clinem\/dgab208","article-title":"Pseudohypoparathyroidism: focus on cerebral and renal calcifications","volume":"106","author":"Mazoni","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"doi-asserted-by":"publisher","key":"2025082803302897000_17.2.e258403.2","DOI":"10.1136\/archdischild-2019-317482"},{"key":"2025082803302897000_17.2.e258403.3","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040718","article-title":"Lactose intolerance and bone health: the challenge of ensuring adequate calcium intake","volume":"11","author":"Hodges","year":"2019","journal-title":"Nutrients"},{"key":"2025082803302897000_17.2.e258403.4","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.f2213","article-title":"Investigating hypocalcaemia","volume":"346","author":"Hannan","year":"2013","journal-title":"BMJ"},{"key":"2025082803302897000_17.2.e258403.5","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1210\/clinem\/dgab060","article-title":"Molecular definition of pseudohypoparathyroidism variants","volume":"106","author":"J\u00fcppner","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082803302897000_17.2.e258403.6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5144\/0256-4947.2013.411","article-title":"Dental findings in the diagnosis of idiopathic hypoparathyroidism","volume":"33","author":"Kamarthi","year":"2013","journal-title":"Ann Saudi Med"},{"key":"2025082803302897000_17.2.e258403.7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ecl.2018.07.011","article-title":"Pseudohypoparathyroidism","volume":"47","author":"Linglart","year":"2018","journal-title":"Endocrinol Metab Clin North Am"},{"doi-asserted-by":"publisher","key":"2025082803302897000_17.2.e258403.8","DOI":"10.1038\/s41574-018-0042-0"},{"doi-asserted-by":"publisher","key":"2025082803302897000_17.2.e258403.9","DOI":"10.1210\/jc.2005-2282"},{"key":"2025082803302897000_17.2.e258403.10","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00701","article-title":"Dental findings in patients with non-surgical hypoparathyroidism and pseudohypoparathyroidism: a systematic review","volume":"9","author":"Hejlesen","year":"2018","journal-title":"Front Physiol"},{"key":"2025082803302897000_17.2.e258403.11","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-019-0978-z","article-title":"Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism","volume":"20","author":"Hejlesen","year":"2019","journal-title":"BMC Oral Health"},{"key":"2025082803302897000_17.2.e258403.12","first-page":"195","article-title":"Primary hypoparathyroidism misdiagnosed as epilepsy - 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