{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:50:58Z","timestamp":1784609458108,"version":"3.55.0"},"reference-count":14,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,10,12]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>In this case, a man in his late 20s visited his general practitioner with unilateral left nipple discharge. Initially, he was treated with antibiotics and the nipple discharge stopped. When the discharge recurred after a few weeks, the patient was referred to the multidisciplinary breast centre in UZ Leuven. Clinical examination revealed an otherwise healthy but obese man (body mass index of 31\u2009kg\/m\u00b2). On examination, we were able to evacuate bloody discharge from a single duct by mild compression of the left nipple.<\/jats:p>\n               <jats:p>The bilateral mammography and ultrasound showed an irregular retroareolar density of 40\u00d750\u2009mm with adjacent, multiple clustered microcalcifications over a total distance of 20\u2009mm on the left side.<\/jats:p>\n               <jats:p>The histopathological report after core needle biopsy revealed a poorly differentiated ductal carcinoma <jats:italic>in situ<\/jats:italic>. Genetic testing for hereditary breast\u2013ovarian cancer genes was negative. A simple left mastectomy with sentinel lymph node biopsy was performed. There was no indication for adjuvant chemotherapy or radiotherapy, nor for adjuvant endocrine therapy.<\/jats:p>","DOI":"10.1136\/bcr-2023-258447","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:55:15Z","timestamp":1740441315000},"page":"e258447","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Male ductal carcinoma <i>in situ<\/i> (DCIS) at a young age"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9967-9499","authenticated-orcid":false,"given":"Emma","family":"Vastmans","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology, Maastricht UMC+, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sileny","family":"Han","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, KU Leuven University Hospitals, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Floris","sequence":"additional","affiliation":[{"name":"Pathology, KU Leuven University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Neven","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, KU Leuven University Hospitals, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2025082801584062000_18.2.e258447.1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s10549-021-06174-y","article-title":"Management and outcomes of men diagnosed with primary breast cancer","volume":"188","author":"Johnson","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"2025082801584062000_18.2.e258447.2","article-title":"An Update on the General Features of Breast Cancer in Male Patients-A Literature Review","volume":"12","author":"Ionescu","year":"2022","journal-title":"Diagn (Basel)"},{"key":"2025082801584062000_18.2.e258447.3","first-page":"S120","article-title":"DCIS in Male and Aged Women with Comorbidities","volume":"116","author":"Krawczyk","year":"2021","journal-title":"Chir Buc"},{"key":"2025082801584062000_18.2.e258447.4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10549-022-06689-y","article-title":"Ductal carcinoma in situ of the male breast: clinical radiological features and management in a cancer referral center","volume":"196","author":"Nicosia","year":"2022","journal-title":"Breast Cancer Res Treat"},{"key":"2025082801584062000_18.2.e258447.5","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.229"},{"key":"2025082801584062000_18.2.e258447.6","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.4166","article-title":"Ductal carcinoma in situ (DCIS) presenting as a cystic retroareolar lesion in an African American man","volume":"9","author":"Ndumele","year":"2021","journal-title":"Clin Case Rep"},{"key":"2025082801584062000_18.2.e258447.7","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1707939"},{"key":"2025082801584062000_18.2.e258447.8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1067\/j.cpradiol.2018.01.002","article-title":"Male Breast Magnetic Resonance Imaging: When is it Helpful? Our Experience Over the Last Decade","volume":"48","author":"Shin","year":"2019","journal-title":"Curr Probl Diagn Radiol"},{"key":"2025082801584062000_18.2.e258447.9","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1007\/s00268-008-9713-7","article-title":"Diagnosis and management of male breast cancer","volume":"32","author":"Lanitis","year":"2008","journal-title":"World J Surg"},{"key":"2025082801584062000_18.2.e258447.10","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwad006"},{"key":"2025082801584062000_18.2.e258447.11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.14740\/wjon1644","article-title":"The Role of Crohn Disease on Breast Cancer Incidence: A Clinical Analysis","volume":"14","author":"Patel","year":"2023","journal-title":"World J Oncol"},{"key":"2025082801584062000_18.2.e258447.12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/ibd\/izx062","article-title":"Neoplasia and Precursor Lesions of the Female Genital Tract in IBD: Epidemiology, Role of Immunosuppressants, and Clinical Implications","volume":"24","author":"Hazenberg","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2025082801584062000_18.2.e258447.13","doi-asserted-by":"crossref","DOI":"10.1007\/s11894-020-0747-9","article-title":"The Complex Interplay Between Inflammatory Bowel Disease and Malignancy","volume":"22","author":"Kimmel","year":"2020","journal-title":"Curr Gastroenterol Rep"},{"key":"2025082801584062000_18.2.e258447.14","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s11739-023-03281-0","article-title":"Crohn\u2019s disease and breast cancer: a literature review of the mechanisms and treatment","volume":"18","author":"Zhou","year":"2023","journal-title":"Intern Emerg Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-258447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:58:50Z","timestamp":1756371530000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-258447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,24]]},"published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1136\/bcr-2023-258447"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-258447","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}