{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:10:02Z","timestamp":1756325402870,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,1]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>More than 5 years previous to this report, a female patient in her 60s underwent oncological left-sided pancreatic resection and adrenalectomy including splenectomy for locally advanced pancreatic adenocarcinoma (PDAC), recommended by a multidisciplinary tumour board (MDT). Additionally, she was treated with gemcitabine-containing hyperthermic intraperitoneal chemotherapy (HIPEC) for 60\u2009minutes in the framework of a clinical trial (PanHIPEC), aiming to determine the safety and feasibility (not efficacy) of this approach. Following the postoperative MDT recommendation, she subsequently received adjuvant chemotherapy consisting of six cycles of gemcitabine and cisplatin for a histopathologically confirmed PDAC of the pancreatic tail with infiltration of the left-sided adrenal gland (pT3, pN1 (3\/16), cM0, L0, V0, Pn1, R0, G2). Five years and five\u2009months after pancreatic surgery and HIPEC, the patient has no signs of tumour recurrence as determined by follow-up examination including CT scan and CA19-9 tumour marker serology.<\/jats:p>","DOI":"10.1136\/bcr-2023-258626","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T12:55:36Z","timestamp":1708347336000},"page":"e258626","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term recurrence-free survival following pancreatic surgery with HIPEC treatment for locally advanced pancreatic adenocarcinoma"],"prefix":"10.1136","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct02863471","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Valerie","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Frauenfeld","sequence":"additional","affiliation":[{"name":"Department of Pathology and Neuropathology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-1317","authenticated-orcid":false,"given":"Markus W.","family":"L\u00f6ffler","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Department of Clinical Pharmacology, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Cluster of Excellence iFIT (EXC2180) \"Image-Guided and Functionally Instructed Tumor Therapies\", University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 L.","family":"Mihaljevic","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9720-8243","authenticated-orcid":false,"given":"Can","family":"Yurttas","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"2025082712343169000_17.2.e258626.1","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.3748\/wjg.v21.i11.3157","article-title":"Update on the management of Pancreatic cancer: surgery is not enough","volume":"21","author":"Ansari","year":"2015","journal-title":"World J 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