{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:40:22Z","timestamp":1756294822339,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular, benign and locally aggressive tumour that predominantly affects adolescent males. Recognised for its persistence and propensity to recur, patients usually present with gradual development of symptoms such as epistaxis and nasal obstruction over several months to years. Diagnosis typically combines clinical assessments and radiographic studies, often involving preoperative angiography to identify feeder vessels and facilitate embolisation, reducing intraoperative bleeding during surgical interventions. A comprehensive approach to treatment, considering both tumour characteristics and patient well-being, is crucial, particularly when dealing with cases involving intracranial extension. Surgical excision remains the primary treatment for angiofibroma, though radiotherapy is considered for cases with intracranial extension. This case report outlines a case involving a young man in his 20s with a large bilateral JNA extending into the intracranial area. The patient underwent preoperative embolisation followed by surgical resection using a nasofrontomaxillary swing approach with a bifrontal craniotomy window. This alternative approach provided enhanced exposure to address the involvement of the infratemporal fossa, anterior and middle skull base. Postoperatively, residual intracranial tumour was managed with radiation therapy. Over a 2-year follow-up, the patient remains asymptomatic, with a minor postradiation reduction in the intracranial component\u2019s size.<\/jats:p>","DOI":"10.1136\/bcr-2023-258641","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:52:03Z","timestamp":1724287923000},"page":"e258641","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Challenges and innovations in managing a complex giant bilateral juvenile nasopharyngeal angiofibroma with intracranial extension"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5669-3811","authenticated-orcid":false,"given":"Reshma","family":"Eugine","sequence":"first","affiliation":[{"name":"Otorhinolaryngology, All India Institute of Medical Sciences\u2014Rishikesh, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-3691","authenticated-orcid":false,"given":"Suji","family":"PS","sequence":"additional","affiliation":[{"name":"ENT, All India Institute of Medical Sciences\u2014Rishikesh, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-9664","authenticated-orcid":false,"given":"Abhishek","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, All India Institute of Medical Sciences\u2014Rishikesh, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-2138","authenticated-orcid":false,"given":"Madhu Priya","family":"Sahu","sequence":"additional","affiliation":[{"name":"AIIMS Rishikesh, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"2025082704040238000_17.8.e258641.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)01580-8"},{"key":"2025082704040238000_17.8.e258641.2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jcms.2005.08.006","article-title":"Surgical approaches to juvenile nasopharyngeal angiofibroma","volume":"34","author":"Cansiz","year":"2006","journal-title":"J Craniomaxillofac Surg"},{"key":"2025082704040238000_17.8.e258641.3","doi-asserted-by":"crossref","unstructured":"Nagarkar NM , Singh A , Mehta R . 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