{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:49:46Z","timestamp":1770918586924,"version":"3.50.1"},"reference-count":8,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,29]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Eumycetoma, a subcutaneous infection caused by various fungi with pathognomonic discharging grain, is rarely reported in Malaysia. This case concerns a eumycetoma infection in an immunocompetent man who presented with progressive left foot swelling complicated with pustules, sinuses and pale grain discharge for the past year after recurrent thorn pricks. Histological findings of the grain and tissue showed foci of septate fungal hyphae. Tissue culture yielded no growth. Amplification and sequencing of the rDNA internal transcribed spacer 1 (ITS1), ITS4 and large subunit regions of the tissue identified the causative agent as <jats:italic>Fusarium falciforme<\/jats:italic>, highlighting the role of molecular diagnostic method in identifying fungal species in eumycetoma. The patient was treated with surgical excision and oral itraconazole with excellent improvement. However, he presented again with recurrence after defaulting therapy. <jats:italic>F. falciforme<\/jats:italic> has been implicated in causing diseases in crops and sea turtles. Therefore, the One Health approach should be adopted to manage this emerging species.<\/jats:p>","DOI":"10.1136\/bcr-2023-258657","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T13:30:25Z","timestamp":1709904625000},"page":"e258657","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Fusarium falciforme<\/i> eumycetoma: a diagnostic challenge of a neglected tropical disease"],"prefix":"10.1136","volume":"17","author":[{"given":"Noralwani","family":"Badarol Hisham","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Universiti Putra Malaysia Fakulti Perubatan dan Sains Kesihatan, Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaharuddin","family":"Abdul Rhani","sequence":"additional","affiliation":[{"name":"Orthopaedic Department, KPJ Selangor Specialist Hospital, Shah Alam, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razana","family":"Mohd Ali","sequence":"additional","affiliation":[{"name":"Pathology Department, Universiti Putra Malaysia Fakulti Perubatan dan Sains Kesihatan, Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti Norbaya","family":"Masri","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Universiti Putra Malaysia Fakulti Perubatan dan Sains Kesihatan, Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"2025082722351009000_17.3.e258657.1","unstructured":"World Health Organization . Eumycetoma fact sheet. 2023. Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mycetoma [Accessed 16 Jul 2023]."},{"key":"2025082722351009000_17.3.e258657.2","first-page":"104","article-title":"Fungal and bacterial mycetoma diagnosis from a histological perspective: a local report of two cases involving foreign labourers","volume":"17","author":"Balqis","year":"2021","journal-title":"Mal J Med Health Sci"},{"key":"2025082722351009000_17.3.e258657.3","first-page":"107","article-title":"\u201cShoulder mycetoma with 'DOT-in-circle' sign\u201d","volume":"17","author":"Ahmad","year":"2021","journal-title":"Mal J Med Health Sci"},{"key":"2025082722351009000_17.3.e258657.4","doi-asserted-by":"crossref","DOI":"10.3390\/jof9070730","article-title":"The first case of Fusarium falciforme eumycetoma in Sudan and an extensive literature review about treatment worldwide","volume":"9","author":"Siddig","year":"2023","journal-title":"J Fungi (Basel)"},{"key":"2025082722351009000_17.3.e258657.5","doi-asserted-by":"crossref","DOI":"10.5070\/D319M6R34K","article-title":"Actinomycetoma with negative culture: a therapeutic challenge","volume":"14","author":"Liu","year":"2008","journal-title":"Dermatol Online J"},{"key":"2025082722351009000_17.3.e258657.6","doi-asserted-by":"crossref","first-page":"106205","DOI":"10.1016\/j.actatropica.2021.106205","article-title":"The developed molecular biological identification tools for mycetoma causative agents: an update","volume":"225","author":"Siddig","year":"2022","journal-title":"Acta Tropica"},{"key":"2025082722351009000_17.3.e258657.7","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/tmi.13828","article-title":"Diagnostics to support mycetoma management\u2014development of two target product profiles","volume":"27","author":"Fongwen","year":"2022","journal-title":"Trop Med Int Health"},{"key":"2025082722351009000_17.3.e258657.8","doi-asserted-by":"crossref","DOI":"10.3390\/jof6040235","article-title":"A one health perspective to recognize Fusarium as important in clinical practice","volume":"6","author":"S\u00e1enz","year":"2020","journal-title":"J Fungi (Basel)"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-258657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:35:20Z","timestamp":1756359320000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-258657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,8]]},"published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1136\/bcr-2023-258657"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-258657","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}