{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:43:39Z","timestamp":1782315819571,"version":"3.54.5"},"reference-count":10,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,5]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Neonatal jaundice is a frequently observed occurrence in full-term newborns and typically manifests between 48 and 96 hours following birth. Early-onset jaundice is primarily induced by pathological factors, namely sepsis, hemolysis and an excessive accumulation of bilirubin resulting from the breakdown of red blood cells.<\/jats:p>\n               <jats:p>We present a case involving a full-term newborn with an uneventful perinatal history, who exhibited jaundice within the initial day of life and was subsequently admitted to the neonatal intensive care unit to commence intensive phototherapy. Initial screenings for sepsis and blood group incompatibility yielded negative results. However, despite 6\u2009hours of phototherapy, the bilirubin levels did not decrease, prompting an investigation into central nervous system haemorrhage, which uncovered the presence of a haemorrhagic stroke.<\/jats:p>\n               <jats:p>After a worsening in neurological status with neonatal crisis and need for phenobarbital, a life-saving craniotomy was performed. Clinical evolution was good with no additional crisis detected after the early neonatal period and improvement in motor function at 2-month-old follow-up.<\/jats:p>","DOI":"10.1136\/bcr-2023-258661","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T12:35:27Z","timestamp":1707914127000},"page":"e258661","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Rare cause of jaundice in a term newborn"],"prefix":"10.1136","volume":"17","author":[{"given":"In\u00eas Silva","family":"Costa","sequence":"first","affiliation":[{"name":"Neonatology Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Pediatrics Department, Centro Hospitalar Tondela Viseu EPE, Viseu, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Vala","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Centro Hospitalar Leiria EPE, Pousos, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Costa","sequence":"additional","affiliation":[{"name":"Neonatology Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Henriques","sequence":"additional","affiliation":[{"name":"Neonatology Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"2025082711123062000_17.2.e258661.1","unstructured":"Gomella TL , Eyal FG , Bany-Mohammed F . Gomella\u2019s Neonatology: Management, procedures, on-call problems, diseases and drugs. 8th edition. USA: McGraw Hill, Lange, 2020: 546\u201357."},{"key":"2025082711123062000_17.2.e258661.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(10)60027-7"},{"key":"2025082711123062000_17.2.e258661.3","unstructured":"National Institute for Health and Care Excellence . Jaundice in newborn babies under 28 days. London: NICE Clinical Guidelines, 2016: 29p."},{"key":"2025082711123062000_17.2.e258661.4","doi-asserted-by":"publisher","DOI":"10.1136\/fetalneonatal-2010-196451"},{"key":"2025082711123062000_17.2.e258661.5","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160253","article-title":"Findings and differential diagnosis of fetal intracranial haemorrhage and fetal ischaemic brain injury: what is the role of fetal MRI?","volume":"90","author":"Putbrese","year":"2017","journal-title":"Br J Radiol"},{"key":"2025082711123062000_17.2.e258661.6","doi-asserted-by":"crossref","first-page":"F88","DOI":"10.1136\/fn.76.2.F88","article-title":"Unilateral neonatal cerebral infarction in full term infants","volume":"76","author":"Estan","year":"1997","journal-title":"Archives of Disease in Childhood - Fetal and Neonatal Edition"},{"key":"2025082711123062000_17.2.e258661.7","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811408424"},{"key":"2025082711123062000_17.2.e258661.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2019.08.003"},{"key":"2025082711123062000_17.2.e258661.9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/jamapediatrics.2016.4151","article-title":"Clinical Characteristics, Risk Factors, and Outcomes Associated With Neonatal Hemorrhagic Stroke: A Population-Based Case-Control Study","volume":"171","author":"Cole","year":"2017","journal-title":"JAMA Pediatr"},{"key":"2025082711123062000_17.2.e258661.10","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000183"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-258661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:12:40Z","timestamp":1756318360000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-258661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,14]]},"published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1136\/bcr-2023-258661"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-258661","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}