{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:14:27Z","timestamp":1790374467246,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,4,9]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Mycetoma is a chronic granulomatous infectious disease with a triad of subcutaneous swelling, discharging sinuses and the presence of granules. The infection may occur following minor trauma or penetrating thorn injury. We report a case of a man in his 40s with a history of thorn prick 9 years ago, followed by the formation of painless discharging sinuses on the right foot for the past 2 years. Clinical, local epidemiological, histopathological examination and Gram stain confirmed the diagnosis of actinomycetoma. Prior to initiating the Welsh regimen, a pretreatment assessment of the patient\u2019s auditory function was conducted through pure tone audiometry, indicating the existence of pre-existing high-frequency bilateral sensorineural hearing loss. The patient was treated with linezolid as an alternative to amikacin, at a dosage of 600\u2009mg two times per day, leading to complete resolution within 3\u2009weeks. This underscores linezolid\u2019s efficacy as a safe and cost-effective alternative for actinomycetoma, without causing ototoxic side effects.<\/jats:p>","DOI":"10.1136\/bcr-2023-258686","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T16:19:24Z","timestamp":1717604364000},"page":"e258686","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Actinomycetoma in a patient with pre-existing sensorineural hearing loss: a linezolid-based treatment paradigm"],"prefix":"10.1136","volume":"17","author":[{"given":"Kirti","family":"Deo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Masare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham Vijay","family":"Deokar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"2024060408441509000_17.4.e258686.1","doi-asserted-by":"crossref","DOI":"10.3390\/tropicalmed3030097","article-title":"Mycetoma: the spectrum of clinical presentation","volume":"3","author":"Fahal","year":"2018","journal-title":"Trop Med Infect Dis"},{"key":"2024060408441509000_17.4.e258686.2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clindermatol.2006.05.011","article-title":"Mycetoma","volume":"25","author":"Welsh","year":"2007","journal-title":"Clin Dermatol"},{"key":"2024060408441509000_17.4.e258686.3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002550","article-title":"Global burden of human mycetoma: a systematic review and meta-analysis","volume":"7","author":"van de Sande","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"2024060408441509000_17.4.e258686.4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003218","article-title":"Mycetoma medical therapy","volume":"8","author":"Welsh","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"2024060408441509000_17.4.e258686.6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.25259\/IJDVL_125_20","article-title":"Linezolid: a novel treatment option for the treatment of a non-responsive case of actinomycotic mycetoma","volume":"87","author":"Patra","year":"2021","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2024060408441509000_17.4.e258686.7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s40506-018-0171-y","article-title":"Current treatment of mycetoma","volume":"10","author":"Welsh","year":"2018","journal-title":"Curr Treat Options Infect Dis"},{"key":"2024060408441509000_17.4.e258686.8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/jomfp.JOMFP_79_18","article-title":"Splendore\u2013Hoeppli phenomenon","volume":"22","author":"Gopinath","year":"2018","journal-title":"J Oral Maxillofac Pathol"},{"key":"2024060408441509000_17.4.e258686.9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.9.6.956"},{"key":"2024060408441509000_17.4.e258686.10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/cncr.29779","article-title":"Ototoxicity and cancer therapy","volume":"122","author":"Landier","year":"2016","journal-title":"Cancer"},{"key":"2024060408441509000_17.4.e258686.11","doi-asserted-by":"publisher","DOI":"10.2174\/138161207779313731"},{"key":"2024060408441509000_17.4.e258686.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00086-6"},{"key":"2024060408441509000_17.4.e258686.13","unstructured":"Wolverton SE , Wu JJ . Comprehensive dermatologic drug therapy. Elsevier Health Sciences, 2019."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-258686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T16:19:31Z","timestamp":1717604371000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-258686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,24]]},"published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1136\/bcr-2023-258686"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-258686","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}