{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:51:19Z","timestamp":1775022679083,"version":"3.50.1"},"reference-count":29,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,7,1]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Adenoid cystic carcinoma (ACC) is a rare tumour of the salivary glands characterised by distant metastases, mainly to lungs and bone. Isolated metastasis to the liver is unusual. We present the case of a woman with an ACC of the submandibular gland (pT1N0) who underwent radical submandibular gland excision and selective neck dissection. Preoperative imaging identified a liver lesion with features suggestive of a haemangioma. Two-year postoperatively, a surveillance CT neck\/trunk showed an increase in size of the left liver lobe lesion. Subsequent MR liver and US-guided biopsy confirmed the lesion to be metastatic ACC. The patient underwent a successful left lateral liver sectionectomy. She remains disease-free 2.5 years after her liver resection. A literature search revealed only four other similar cases. This report highlights that even early-stage ACCs of the salivary gland may present with synchronous solitary liver metastasis which can be effectively treated with curative surgery.<\/jats:p>","DOI":"10.1136\/bcr-2023-258923","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:55:44Z","timestamp":1721652944000},"page":"e258923","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Solitary liver metastasis from adenoid cystic carcinoma of the submandibular gland"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-9578","authenticated-orcid":false,"given":"Svetlana Doris","family":"Brincat","sequence":"first","affiliation":[{"name":"Division of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, UK"},{"name":"Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Cassar","sequence":"additional","affiliation":[{"name":"Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"2025082702565818000_17.7.e258923.1","unstructured":"Young A , Okuyemi OT . Malignant salivary gland tumors 2022. Treasure Island, FL: StatPearls Publishing, 2022."},{"key":"2025082702565818000_17.7.e258923.2","unstructured":"Ammad Ud Din M , Shaikh H . Adenoid cystic cancer. 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