{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:06:34Z","timestamp":1756339594963,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,5,18]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Primary cardiac angiosarcomas are extremely rare, highly aggressive tumours with rapid progression and high metastatic capability. More than 60% of tumours are detected after the onset of a metastatic disease. In the two cases presented, we demonstrate the role of muti-modality imaging in the diagnosis of the lesion and provide valuable input in prognosticating the disease burden. In both cases, the diagnosis was suspected initially by imaging, based on radiological observations, before the final histopathology confirmation was made. Positron emission tomography\u2013 (PET-CT) was a critical component of the diagnostic workup for the detection of disease extent and volume of total disease burden. Hence, PET-CT imaging should be performed in all aggressive appearing cardiac tumours. In view of misleading clinical presentation, we suggest that aggressive workup to be performed in suspected patients. Young patients presenting with vague symptoms and those with recurrent, unresolving, unexplained pericardial effusion deserves special consideration.<\/jats:p>","DOI":"10.1136\/bcr-2023-259022","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T22:45:28Z","timestamp":1719269128000},"page":"e259022","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging primary cardiac angiosarcoma: case-based illustrations with multimodality imaging and emphasis on the role of positron emission tomography-CT"],"prefix":"10.1136","volume":"17","author":[{"given":"Ann Mary","family":"Jose","sequence":"first","affiliation":[{"name":"Radiology, Narayana Hrudayalaya Health City Bangalore, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gadabanahalli","family":"Karthik","sequence":"additional","affiliation":[{"name":"Radiology, Narayana Hrudayalaya Health City Bangalore, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep Kumar","family":"Shetty","sequence":"additional","affiliation":[{"name":"Cardiology, Narayana Hrudayalaya Health City Bangalore, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0220-2584","authenticated-orcid":false,"given":"Venkatraman","family":"Bhat","sequence":"additional","affiliation":[{"name":"Radiology, Narayana Hrudayalaya Health City Bangalore, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"O\u0142ownia A , Orczyk J , Tokarzewska A , et al . n.d. Diagnosis and treatment of cardiac Angiosarcoma. J Educ Health Sport 40:20\u20135. doi:10.12775\/JEHS.2023.40.01.002","key":"2025082711550950000_17.6.e259022.1","DOI":"10.12775\/JEHS.2023.40.01.002"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.2","DOI":"10.1097\/COC.0b013e31827e4e7b"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.3","DOI":"10.1002\/1097-0142(19860215)57:4<852::AID-CNCR2820570428>3.0.CO;2-S"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.4","DOI":"10.1097\/00000658-198002000-00001"},{"key":"2025082711550950000_17.6.e259022.5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1055\/s-2007-1014065","article-title":"Primary cardiac tumors - French studies of 533 cases","volume":"38 Suppl 2","author":"Blondeau","year":"1990","journal-title":"Thorac Cardiovasc Surg"},{"key":"2025082711550950000_17.6.e259022.6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3390\/diagnostics10100776","article-title":"Clinical and imaging features of primary cardiac Angiosarcoma","volume":"10","author":"Chen","year":"2020","journal-title":"Diagnostics"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.7","DOI":"10.1016\/0002-8703(94)90149-X"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.8","DOI":"10.1259\/bjr.20170039"},{"key":"2025082711550950000_17.6.e259022.9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2463\/mrms.cr.2015-0082","article-title":"Sun Ray\u201d appearance in a case of cardiac Angiosarcoma: A comparison of MRI and PET\/CT","volume":"16","author":"T\u00fcd\u00f6s","year":"2017","journal-title":"Magn Reson Med Sci"},{"doi-asserted-by":"crossref","unstructured":"Yu J-F , Cui H , Ji G-M , et al . Clinical and imaging manifestations of primary cardiac Angiosarcoma. BMC Med Imaging 2019;19. doi:10.1186\/s12880-019-0318-4","key":"2025082711550950000_17.6.e259022.10","DOI":"10.1186\/s12880-019-0318-4"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.11","DOI":"10.1177\/0284185115571789"},{"doi-asserted-by":"crossref","unstructured":"Li X , Lan L , Hu H . Case report: primary cardiac Angiosarcoma with multiple metastases. Front Cardiovasc Med 2022;9. doi:10.3389\/fcvm.2022.941967","key":"2025082711550950000_17.6.e259022.12","DOI":"10.3389\/fcvm.2022.941967"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.13","DOI":"10.2214\/ajr.180.6.1801671"},{"key":"2025082711550950000_17.6.e259022.14","doi-asserted-by":"crossref","DOI":"10.1177\/1758835918793569","article-title":"18F-FDG-PET\/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature","volume":"10","author":"Saponara","year":"2018","journal-title":"Ther Adv Med Oncol"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.15","DOI":"10.1148\/radiol.2015140564"},{"key":"2025082711550950000_17.6.e259022.16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.clinimag.2016.11.016","article-title":"FDG PET\/MR in initial staging of sarcoma: initial experience and comparison with conventional imaging","volume":"42","author":"Platzek","year":"2017","journal-title":"Clin Imaging"},{"unstructured":"Becker AE . Tumors of the heart and Pericardium. In: Fletcher C , ed. Diagnostic Histopathology of tumors. 2000: 7\u201344.","key":"2025082711550950000_17.6.e259022.17"},{"key":"2025082711550950000_17.6.e259022.18","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/j.carpath.2010.09.006","article-title":"A rare cardiac Neoplasm: case report of cardiac epithelioid Angiosarcoma","volume":"20","author":"Matzke","year":"2011","journal-title":"Cardiovasc Pathol"},{"doi-asserted-by":"publisher","key":"2025082711550950000_17.6.e259022.19","DOI":"10.1136\/jclinpath-2014-202629"},{"key":"2025082711550950000_17.6.e259022.20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.humpath.2016.10.014","article-title":"Cardiac Angiosarcoma: histopathologic, immunohistochemical, and Cytogenetic analysis of 10 cases","volume":"60","author":"Leduc","year":"2017","journal-title":"Hum Pathol"},{"key":"2025082711550950000_17.6.e259022.21","first-page":"94","article-title":"Successful surgical treatment for primary cardiac Angiosarcoma: a case report","volume":"2","author":"Suehiro","year":"2023","journal-title":"Gen Thorac Cardiovasc Surg Cases"},{"key":"2025082711550950000_17.6.e259022.22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.xjon.2021.08.038","article-title":"Outcomes after resection of primary cardiac sarcoma","volume":"8","author":"Hasan","year":"2021","journal-title":"JTCVS Open"},{"key":"2025082711550950000_17.6.e259022.23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/COC.0000000000000106","article-title":"Primary cardiac sarcoma: 25-year Cleveland clinic experience","volume":"39","author":"Randhawa","year":"2016","journal-title":"Am J Clin Oncol"},{"key":"2025082711550950000_17.6.e259022.24","first-page":"944","article-title":"A 30-year-old man with primary cardiac Angiosarcoma","volume":"3","author":"Jex","year":"2021","journal-title":"JACC: Case Reports"},{"doi-asserted-by":"crossref","unstructured":"Wang L , Lao IW , Yu L , et al . n.d. Clinicopathological features and Prognostic factors in Angiosarcoma: a retrospective analysis of 200 patients from a single Chinese medical Institute. Oncol Lett 14:5370\u20138. doi:10.3892\/ol.2017.6892","key":"2025082711550950000_17.6.e259022.25","DOI":"10.3892\/ol.2017.6892"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-259022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:55:18Z","timestamp":1756320918000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-259022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,24]]},"published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1136\/bcr-2023-259022"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-259022","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,6]]}}}