{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:05Z","timestamp":1756425785244,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,11,8]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Phenotypic plasticity refers to the ability of tumour cells to undergo molecular and phenotypic changes in response to microenvironmental stresses, genetic and epigenetic alterations, or treatment-induced selective pressures, thereby promoting tumour progression. This case report discusses a man in his 70s with pleomorphic adenoma of the parotid, where phenotypic plasticity led to the development of pleomorphic liposarcoma in the parotid through transdifferentiation. Sarcomas can arise in the parotid from pre-existing pleomorphic adenomas or de novo, with only eight reported cases of primary parotid liposarcoma. The less studied pathway is the adenoma-carcinoma-sarcoma progression in pleomorphic adenoma of the parotid. This case report and literature review aim to investigate this evolutionary process and its implications for treatment planning and management from a surgical oncologist\u2019s perspective.<\/jats:p>","DOI":"10.1136\/bcr-2023-259115","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T20:31:18Z","timestamp":1733344278000},"page":"e259115","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic plasticity in parotid tumours: insights from a surgical oncologist\u2019s perspective"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9733-0257","authenticated-orcid":false,"given":"Naveen kumar","family":"Kushwaha","sequence":"first","affiliation":[{"name":"Surgical Oncology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-4472","authenticated-orcid":false,"given":"Pradeep","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish Shiva","family":"Murthy","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan Kumar","family":"Dhaman","sequence":"additional","affiliation":[{"name":"Pathology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"2025082800352544000_17.12.e259115.1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"2025082800352544000_17.12.e259115.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"2025082800352544000_17.12.e259115.3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.anorl.2018.01.013","article-title":"Primary parotid liposarcoma","volume":"136","author":"Ko\u0161ec","year":"2019","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"2025082800352544000_17.12.e259115.4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314891","article-title":"The Therapeutic Landscape of Salivary Gland Malignancies-Where Are We Now?","volume":"23","author":"Cleymaet","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025082800352544000_17.12.e259115.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00449"},{"key":"2025082800352544000_17.12.e259115.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.05.005"},{"key":"2025082800352544000_17.12.e259115.7","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14194862","article-title":"Systematic Review of Parotid Gland Sarcomas: Multi-Variate Analysis of Clinicopathologic Findings, Therapeutic Approaches and Oncological Outcomes That Affect Survival Rate","volume":"14","author":"Colizza","year":"2022","journal-title":"Cancers (Basel)"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-259115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:35:33Z","timestamp":1756366533000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-259115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":7,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,4]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bcr-2023-259115"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-259115","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}