{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:10:02Z","timestamp":1756314602776,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,5,22]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Malignant struma ovarii (MSO) is a rare ovarian teratoma composed primarily of thyroid tissue. Common sites of metastasis include peritoneum, bone, liver, lung, gastrointestinal tract and omentum. We present a woman in her 50s with a history of remote oophorectomy presenting with hypopituitarism and a 2.7 cm sellar mass. Trans-sphenoidal surgery for presumed pituitary macroadenoma achieved near total resection and resultant pathology surprisingly showed ectopic thyroid tissue. The patient acquired her ovarian pathology report from Southeast Asia which showed struma ovarii of the left ovary. The pituitary mass was thus determined to be a metastatic lesion from MSO. She underwent total thyroidectomy and radioactive iodine ablation therapy with good initial response and no regrowth of the tissue or emergence of distant metastases after 5 years of annual follow-up. To our knowledge, this is the first reported case of MSO to the pituitary.<\/jats:p>","DOI":"10.1136\/bcr-2023-259391","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T16:29:09Z","timestamp":1717518549000},"page":"e259391","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Metastatic malignant struma ovarii to the pituitary presenting as a sellar mass and responding to total thyroidectomy with adjuvant radioactive iodine therapy"],"prefix":"10.1136","volume":"17","author":[{"given":"Ashini","family":"Dissanayake","sequence":"first","affiliation":[{"name":"Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology ; Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Gooderham","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery ; Department of Surgery, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"MacKenzie-Feder","sequence":"additional","affiliation":[{"name":"Division of Endocrinology ; Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"2025082709543410000_17.6.e259391.1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.prp.2005.04.004","article-title":"Malignant Struma Ovarii: a case report","volume":"201","author":"Bolat","year":"2005","journal-title":"Pathol Res Pract"},{"doi-asserted-by":"publisher","key":"2025082709543410000_17.6.e259391.2","DOI":"10.5858\/134.5.786"},{"key":"2025082709543410000_17.6.e259391.3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1080\/17843286.2021.1944583","article-title":"Metastatic malignant Struma Ovarii: a case report and review of the literature on the management of malignant Struma Ovarii","volume":"77","author":"Taelman","year":"2022","journal-title":"Acta Clin Belg"},{"doi-asserted-by":"publisher","key":"2025082709543410000_17.6.e259391.4","DOI":"10.1016\/j.ygyno.2004.06.003"},{"key":"2025082709543410000_17.6.e259391.5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jocn.2021.09.016","article-title":"Pituitary metastasis: from pathology to clinical and radiological considerations","volume":"93","author":"Kameda-Smith","year":"2021","journal-title":"J Clin Neurosci"},{"key":"2025082709543410000_17.6.e259391.6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12020-012-9806-9","article-title":"Pituitary metastasis of thyroid cancer","volume":"43","author":"Barbaro","year":"2013","journal-title":"Endocrine"},{"key":"2025082709543410000_17.6.e259391.7","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.3390\/curroncol29120712","article-title":"Highly differentiated follicular carcinoma of ovarian origin: a systematic review of the literature","volume":"29","author":"Giovannopoulou","year":"2022","journal-title":"Curr Oncol"},{"key":"2025082709543410000_17.6.e259391.8","first-page":"147","article-title":"Malignant Struma Ovarii: good response after thyroidectomy and 131I ablation therapy","volume":"2","author":"Janszen","year":"2008","journal-title":"Clin Med Oncol"},{"doi-asserted-by":"crossref","unstructured":"Cui Y , Yao J , Wang S , et al . 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G469A Mutation and Tert promoter alterations favour malignant Struma Ovarii","volume":"84","author":"Neyrand","year":"2024","journal-title":"Histopathology"},{"doi-asserted-by":"publisher","key":"2025082709543410000_17.6.e259391.11","DOI":"10.1016\/S0090-8258(03)00141-0"},{"doi-asserted-by":"publisher","key":"2025082709543410000_17.6.e259391.12","DOI":"10.1097\/PGP.0b013e3181a27777"},{"key":"2025082709543410000_17.6.e259391.13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/thy.2014.0328","article-title":"Malignant Struma Ovarii: a population-level analysis of a large series of 68 patients","volume":"25","author":"Goffredo","year":"2015","journal-title":"Thyroid"},{"doi-asserted-by":"publisher","key":"2025082709543410000_17.6.e259391.14","DOI":"10.1097\/PGP.0b013e318158e958"},{"key":"2025082709543410000_17.6.e259391.15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ncpendmet0887","article-title":"Malignant Struma Ovarii","volume":"4","author":"Yassa","year":"2008","journal-title":"Nat Rev Endocrinol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-259391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:54:46Z","timestamp":1756313686000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-259391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,4]]},"published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1136\/bcr-2023-259391"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-259391","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,6]]}}}