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We report a male patient in his early 70s treated only with mesalamine for ulcerative colitis (UC) for the past 6 years. He was admitted due to COVID-19 and anaemia secondary to massive haematochezia. The patient underwent total colectomy with end ileostomy, with intraoperative proctoscopy. Tissue biopsy demonstrated typical features of UC; however, atypical lymphoid proliferation of the regional lymph nodes with histological and immunochemical staining results was suggestive of classic Hodgkin lymphoma, nodular sclerosis subtype. The patient was treated with adriamycin, vinblastine and dacarbazine chemotherapy initially successful after 1 session but later opted for palliative care. Due to its rarity, lymphoid neoplasms occurring in the context of IBD are poorly known.<\/jats:p>","DOI":"10.1136\/bcr-2023-259507","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T22:47:45Z","timestamp":1734043665000},"page":"e259507","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rare case of classic Hodgkin lymphoma in a patient with ulcerative colitis"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-7413","authenticated-orcid":false,"given":"Nicole Allyson","family":"Chua","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Cardinal Santos Medical Center, San Juan City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Jose","family":"Sollano","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Cardinal Santos Medical Center, San Juan City, Philippines"},{"name":"Department of Medicine, University of Santo Tomas, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"2025082701102565000_17.12.e259507.1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/201010581502400210","article-title":"Ulcerative Colitis Diagnosed in a Patient after Primary Rectal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Treated","volume":"24","author":"Chan","year":"2015","journal-title":"Proc Singap Healthc"},{"key":"2025082701102565000_17.12.e259507.2","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2021.00115"},{"key":"2025082701102565000_17.12.e259507.3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"key":"2025082701102565000_17.12.e259507.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.21675"},{"key":"2025082701102565000_17.12.e259507.5","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0300"},{"key":"2025082701102565000_17.12.e259507.6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.15406\/ghoa.2019.10.00371","article-title":"Ulcerative colitis and lymphoproliferative","volume":"10","author":"Rodriguez","year":"2019","journal-title":"GHOA"},{"key":"2025082701102565000_17.12.e259507.7","doi-asserted-by":"crossref","unstructured":"Khuroo MS . 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