{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:40:07Z","timestamp":1756284007033,"version":"3.44.0"},"reference-count":58,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,4,25]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>We present the case of a term newborn with trisomy 21 who presented to the paediatric emergency department with periumbilical flare and green-brown discharge from a clamped umbilical cord, initially suspected to be omphalitis. However, it was noticed later, that when the infant strained or cried, a thick, bubbling and offensive green-brown discharge came out of the clamped umbilical cord with umbilical flatus. An ultrasound abdomen and umbilical cord confirmed the presence of a persistent omphalomesenteric duct (POMD). He was then transferred to the paediatric surgical unit. There, he underwent a laparotomy and surgical resection of the POMD and was discharged home 2\u2009days later.<\/jats:p>","DOI":"10.1136\/bcr-2024-259671","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T12:55:50Z","timestamp":1715172950000},"page":"e259671","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent omphalomesenteric duct in an infant with trisomy 21"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-0980","authenticated-orcid":false,"given":"Arameh","family":"Aghababaie","sequence":"first","affiliation":[{"name":"Paediatrics, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Ho","sequence":"additional","affiliation":[{"name":"Paediatrics, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Kelay","sequence":"additional","affiliation":[{"name":"Paediatric Surgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Salt","sequence":"additional","affiliation":[{"name":"Paediatrics, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"2025082701174834000_17.5.e259671.1","doi-asserted-by":"crossref","unstructured":"Admella V , Bett\u00f3nica C , Paules MJ . Persistence of the Omphalomesenteric duct: another cause of acute abdomen. Rev Esp Enferm Dig 2022. doi:10.17235\/reed.2022.9221\/2022","DOI":"10.17235\/reed.2022.9221\/2022"},{"key":"2025082701174834000_17.5.e259671.2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s003830050496","article-title":"Patent Omphalomesenteric duct of the Vermiform Appendix in a neonate: congenital Appendicoumbilical Fistula","volume":"14","author":"Crankson","year":"1998","journal-title":"Pediatr Surg Int"},{"key":"2025082701174834000_17.5.e259671.3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3109\/15513815.2016.1173145","article-title":"Occult adenoma in patent Vitellointestinal duct presenting as an umbilical Fistula: cause for concern","volume":"35","author":"Bhankar","year":"2016","journal-title":"Fetal Pediatr Pathol"},{"key":"2025082701174834000_17.5.e259671.4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1179\/146532810X12637745452112","article-title":"Ectopic gastric and Pancreatic tissue: a rare cause of umbilical discharge","volume":"30","author":"de Silva","year":"2010","journal-title":"Ann Trop Paediatr"},{"key":"2025082701174834000_17.5.e259671.5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1447-0756.1989.tb00182.x","article-title":"Patent Omphalomesenteric duct: a case report and review of Japanese literature","volume":"15","author":"Yamada","year":"1989","journal-title":"Asia Oceania J Obstet Gynaecol"},{"key":"2025082701174834000_17.5.e259671.6","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.116539"},{"key":"2025082701174834000_17.5.e259671.7","doi-asserted-by":"crossref","unstructured":"Periquito IR , Marques T , Lima S , et al . Patent Omphalomesenteric duct: Sectioning the unexpected. BMJ Case Rep 2014. doi:10.1136\/bcr-2014-206553","DOI":"10.1136\/bcr-2014-206553"},{"key":"2025082701174834000_17.5.e259671.8","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.arcped.2004.08.005","article-title":"Fistule omphalo-m\u00e9sent\u00e9rique (\u00e0 propos d\u2019un cas)","volume":"11","author":"Sqalli Houssaini","year":"2004","journal-title":"Archives de P\u00e9diatrie"},{"key":"2025082701174834000_17.5.e259671.9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/RLU.0b013e31817debaa","article-title":"Patent Omphalomesenteric duct demonstrated by intestinal transit scintigraphy","volume":"33","author":"Minutoli","year":"2008","journal-title":"Clin Nucl Med"},{"key":"2025082701174834000_17.5.e259671.10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/00015458.2004.11679538","article-title":"Surgical treatment of patent Omphalomesenteric duct presenting as Faecal umbilical discharge","volume":"104","author":"Giacalone","year":"2004","journal-title":"Acta Chir Belg"},{"key":"2025082701174834000_17.5.e259671.11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.jp.7200329","article-title":"Radiology casebook","volume":"20","author":"Ankola","year":"2000","journal-title":"Patent Omphalomesenteric Duct J Perinatol"},{"key":"2025082701174834000_17.5.e259671.12","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1053\/j.gastro.2010.03.082","article-title":"An infant with yellow umbilical drainage. diagnosis: patent Omphalomesenteric Fistula","volume":"140","author":"Walji-Virani","year":"2011","journal-title":"Gastroenterology"},{"key":"2025082701174834000_17.5.e259671.13","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1997.02170480091015"},{"key":"2025082701174834000_17.5.e259671.14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01395717"},{"key":"2025082701174834000_17.5.e259671.15","first-page":"519","article-title":"Completely patent Omphalomesenteric duct","volume":"53","author":"Tranisi","year":"1968","journal-title":"Nebr State Med J"},{"key":"2025082701174834000_17.5.e259671.16","first-page":"67","article-title":"Vitello-intestinal duct Fistula--a rare presentation of a patent Vitello-intestinal duct: a case report","volume":"16","author":"Ali","year":"2010","journal-title":"Pac Health Dialog"},{"key":"2025082701174834000_17.5.e259671.17","article-title":"Patent Omphalomesenteric duct presenting as an umbilical discharge","volume":"94","author":"Fleming","year":"2001","journal-title":"Ir Med J"},{"key":"2025082701174834000_17.5.e259671.18","first-page":"57","article-title":"Patent Omphalomesenteric duct","volume":"107","author":"Mari\u00f1o","year":"2009","journal-title":"Arch Argent Pediatr"},{"key":"2025082701174834000_17.5.e259671.19","doi-asserted-by":"crossref","unstructured":"Agrawal S , Memon A . Patent Vitellointestinal duct. BMJ Case Rep 2010. doi:10.1136\/bcr.12.2009.2594","DOI":"10.1136\/bcr.12.2009.2594"},{"key":"2025082701174834000_17.5.e259671.20","first-page":"1345","article-title":"The wet Umbilicus: maybe not an umbilical Granuloma","volume":"146","author":"van Bezooijen","year":"2002","journal-title":"Ned Tijdschr Geneeskd"},{"key":"2025082701174834000_17.5.e259671.21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/jcu.20813","article-title":"Postoperative Ileo-Ileal Intussusception following surgical resection of patent Omphalomesenteric duct","volume":"39","author":"Yeo","year":"2011","journal-title":"J Clin Ultrasound"},{"key":"2025082701174834000_17.5.e259671.22","first-page":"90","article-title":"Umbilical core-out operation for a completely patent Vitelline duct","volume":"32","author":"Asano","year":"1981","journal-title":"Z Kinderchir"},{"key":"2025082701174834000_17.5.e259671.23","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-010-0689-5"},{"key":"2025082701174834000_17.5.e259671.24","doi-asserted-by":"crossref","unstructured":"Patel RV , Kumar H , Sinha CK , et al . Neonatal Prolapsed patent Vitellointestinal duct. Case Reports 2013. doi:10.1136\/bcr-2013-010221","DOI":"10.1136\/bcr-2013-010221"},{"key":"2025082701174834000_17.5.e259671.25","first-page":"571","article-title":"Ileal Prolapse through patent Vitello-intestinal duct: a report of 3 cases with review of literature","volume":"13","author":"Lal","year":"1976","journal-title":"Indian Pediatr"},{"key":"2025082701174834000_17.5.e259671.26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000090923","article-title":"Look twice before you clamp: Decapitation of an Omphaloenteric duct","volume":"15","author":"van Tuil","year":"2006","journal-title":"Med Princ Pract"},{"key":"2025082701174834000_17.5.e259671.27","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMicm041171","article-title":"Images in clinical medicine. small-bowel Prolapse through a persistent Omphalomesenteric duct","volume":"353","author":"Saad","year":"2005","journal-title":"N Engl J Med"},{"key":"2025082701174834000_17.5.e259671.28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4274\/balkanmedj.2017.0230","article-title":"Patent Omphalomesenteric duct with protruding bowels through a ruptured Omphalocele","volume":"35","author":"Mammadov","year":"2018","journal-title":"Balkan Med J"},{"key":"2025082701174834000_17.5.e259671.29","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(67)90210-3"},{"key":"2025082701174834000_17.5.e259671.30","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2019-229971","article-title":"Complete Evagination of a patent Vitellointestinal duct and adjacent Ileal limbs from an Omphalocele SAC: an extreme presentation","volume":"12","author":"Sim","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025082701174834000_17.5.e259671.31","first-page":"392","article-title":"Small Omphalocele with Ileal Prolapse through a patent Omphalomesenteric duct. a case report and review of literature","volume":"88","author":"Storms","year":"1988","journal-title":"Acta Chir Belg"},{"key":"2025082701174834000_17.5.e259671.32","doi-asserted-by":"publisher","DOI":"10.1007\/BF02753539"},{"key":"2025082701174834000_17.5.e259671.33","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1016\/j.jpedsurg.2013.03.073","article-title":"Esophageal Atresia, small Omphalocele and Ileal Prolapse through a patent Omphalomesenteric duct: a Methimazole Embryopathy","volume":"48","author":"Panait","year":"2013","journal-title":"J Pediatr Surg"},{"key":"2025082701174834000_17.5.e259671.34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/0022-3859.198157","article-title":"Hernia of the umbilical cord associated with a patent Omphalomesenteric duct","volume":"63","author":"Raicevic","year":"2017","journal-title":"J Postgrad Med"},{"key":"2025082701174834000_17.5.e259671.35","doi-asserted-by":"crossref","unstructured":"Pathak A , Agarwal N , Singh P , et al . Prolapse of inverted Ileal loops through a patent Vitellointestinal duct. BMJ Case Rep 2015. doi:10.1136\/bcr-2015-211563","DOI":"10.1136\/bcr-2015-211563"},{"key":"2025082701174834000_17.5.e259671.36","first-page":"207","article-title":"Patent Vitelline duct with Gangrenous small bowel Prolapse: case report and review of literature","volume":"52","author":"Tadesse","year":"2014","journal-title":"Ethiop Med J"},{"key":"2025082701174834000_17.5.e259671.37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.7196\/sajs.1289","article-title":"Intestinal Prolapse through a persistent Omphalomesenteric duct causing small-bowel obstruction","volume":"50","author":"Pauleau","year":"2012","journal-title":"S Afr J Surg"},{"key":"2025082701174834000_17.5.e259671.38","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0623"},{"key":"2025082701174834000_17.5.e259671.39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1992.tb07216.x"},{"key":"2025082701174834000_17.5.e259671.40","doi-asserted-by":"crossref","DOI":"10.1002\/bjs.1800630611","article-title":"Double Intussusception of the small bowel through a patent Vitello-intestinal duct","volume":"63","author":"Mustafa","year":"1976","journal-title":"Br J Surg"},{"key":"2025082701174834000_17.5.e259671.41","doi-asserted-by":"crossref","unstructured":"Marshall ASJ , Jayapal SSK , Whitburn JAS , et al . Recognising serious umbilical cord anomalies. BMJ Case Rep 2013. doi:10.1136\/bcr-2013-201663","DOI":"10.1136\/bcr-2013-201663"},{"key":"2025082701174834000_17.5.e259671.42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1525-1470.2007.00337.x","article-title":"Combined Omphalomesenteric and Urachal remnants in an 18-month-old girl","volume":"24","author":"Kranbuhl","year":"2007","journal-title":"Pediatr Dermatol"},{"key":"2025082701174834000_17.5.e259671.43","first-page":"617","article-title":"Ascending colon Volvulus due to a Vitelline duct remnant in an elderly patient","volume":"71","author":"Bedard","year":"1979","journal-title":"Am J Gastroenterol"},{"key":"2025082701174834000_17.5.e259671.44","doi-asserted-by":"crossref","first-page":"446","DOI":"10.5505\/tjtes.2012.77609","article-title":"A rare cause of small bowel obstruction in adults: persistent Omphalomesenteric duct","volume":"18","author":"G\u00fcner","year":"2012","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"2025082701174834000_17.5.e259671.45","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1471-0528.1996.tb09707.x","article-title":"Velamentous umbilical cord insertion may be suspected from maternal serum alpha-Fetoprotein and hCG","volume":"103","author":"Heinonen","year":"1996","journal-title":"Br J Obstet Gynaecol"},{"key":"2025082701174834000_17.5.e259671.46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2005.10.592","article-title":"Association of congenital anomalies and umbilical cord cysts","volume":"193","author":"Chapman","year":"2005","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2025082701174834000_17.5.e259671.47","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/uog.7576","article-title":"Umbilical cord cysts in the second and third trimesters: significance and Prenatal approach","volume":"36","author":"Zangen","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2025082701174834000_17.5.e259671.48","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1672"},{"key":"2025082701174834000_17.5.e259671.49","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0002-9378(88)90806-X","article-title":"Fetal Jejunoileal Atresia with persistent Omphalomesenteric duct","volume":"158","author":"Petrikovsky","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"2025082701174834000_17.5.e259671.50","first-page":"254","article-title":"Patent Omphalomesenteric duct and Exomphalos minor: a rare and interesting Association","volume":"92","author":"Chattopadhyay","year":"2007","journal-title":"Int Surg"},{"key":"2025082701174834000_17.5.e259671.51","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007087","article-title":"Ultrasonographic diagnosis and minimally invasive treatment of a patent Urachus associated with a patent Omphalomesenteric duct in a newborn: a case report","volume":"96","author":"Bertozzi","year":"2017","journal-title":"Medicine"},{"key":"2025082701174834000_17.5.e259671.52","doi-asserted-by":"crossref","DOI":"10.1097\/00007611-198202000-00041","article-title":"Patent Urachus associated with completely patent Omphalomesenteric duct","volume":"75","author":"Griffith","year":"1982","journal-title":"South Med J"},{"key":"2025082701174834000_17.5.e259671.53","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s002470050112","article-title":"Dual Patency of the Omphalomesenteric duct and Urachus","volume":"27","author":"Lizerbram","year":"1997","journal-title":"Pediatr Radiol"},{"key":"2025082701174834000_17.5.e259671.54","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/MCD.0b013e3283439657","article-title":"Symmetrical upper limb Peromelia and lower limb Amelia associated with persistent Omphalomesenteric duct: a case report","volume":"20","author":"Puvabanditsin","year":"2011","journal-title":"Clin Dysmorphol"},{"key":"2025082701174834000_17.5.e259671.55","doi-asserted-by":"crossref","unstructured":"Kong CKY , Zi Xean K , Li FX , et al . Umbilical cord anomalies: Antenatal ultrasound findings and postnatal correlation. BMJ Case Rep 2018. doi:10.1136\/bcr-2018-226651","DOI":"10.1136\/bcr-2018-226651"},{"key":"2025082701174834000_17.5.e259671.56","unstructured":"Oprisan A , Llorens R , Chacon J , et al . Persistence of the Omphalomesenteric duct in a newborn. 2020. doi:10.13140\/RG.2.2.31269.83680"},{"key":"2025082701174834000_17.5.e259671.57","first-page":"140","article-title":"Spontaneous regression of patent Omphalo-mesenteric duct","volume":"26","author":"Gangopadhyaya","year":"2007","journal-title":"Indian J Gastroenterol"},{"key":"2025082701174834000_17.5.e259671.58","doi-asserted-by":"crossref","first-page":"106524","DOI":"10.1016\/j.prostaglandins.2020.106524","article-title":"Trisomy 21 impairs Pge2 production in Dermal fibroblasts","volume":"153","author":"Marentette","year":"2021","journal-title":"Prostaglandins Other Lipid Mediat"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-259671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:18:04Z","timestamp":1756282684000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-259671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":58,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,8]]},"published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1136\/bcr-2024-259671"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-259671","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,5]]}}}