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The patient received conservative management, including successive red blood cell transfusion and gradual iNO weaning due to suspected glucose-6-phosphate dehydrogenase (G6PD) deficiency. Discontinuation of iNO led to the resolution of both oxidative haemolysis and methaemoglobinaemia. Subsequent enzymatic assay, conducted 4\u2009months later, confirmed G6PD deficiency. This case highlights a rare instance of concurrent methaemoglobinaemia and oxidative haemolytic anaemia following iNO in a patient with underlying G6PD deficiency.<\/jats:p>","DOI":"10.1136\/bcr-2024-259709","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T22:30:49Z","timestamp":1724970649000},"page":"e259709","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Concomitant oxidative haemolysis and methaemoglobinaemia following inhaled nitric oxide in a patient with G6PD deficiency"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-7124","authenticated-orcid":false,"given":"Alexander Mingjie","family":"Cao Zhang","sequence":"first","affiliation":[{"name":"Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D","family":"Zale","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Tabbara","sequence":"additional","affiliation":[{"name":"Division of Hematology, The Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C","family":"Yui","sequence":"additional","affiliation":[{"name":"Division of Hematology, The Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2025082803040958000_17.8.e259709.1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(08)60073-2","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"371","author":"Cappellini","year":"2008","journal-title":"The Lancet"},{"key":"2025082803040958000_17.8.e259709.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000944"},{"key":"2025082803040958000_17.8.e259709.3","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1002\/ajh.26340","article-title":"Recommendations for diagnosis and treatment of methemoglobinemia","volume":"96","author":"Iolascon","year":"2021","journal-title":"Am J Hematol"},{"key":"2025082803040958000_17.8.e259709.4","unstructured":"Ludlow JT , Wilkerson RG , Nappe TM . Methemoglobinemia. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2023. 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