{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:10:17Z","timestamp":1756282217337,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,10,15]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Various factors limit the acceptability of methadone as an opioid agonist treatment (OAT), in which case, buprenorphine becomes the preferred alternative. The classical approach is to gradually taper methadone to a low dose and buprenorphine is initiated after some opioid-free period, which generally takes weeks. A novel approach known as \u2018microdosing\u2019 or the \u2018Bernese method\u2019 might serve as a valuable alternative. We describe two cases where the patients were successfully transitioned from methadone to buprenorphine using this method.<\/jats:p>","DOI":"10.1136\/bcr-2024-259716","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T12:10:27Z","timestamp":1730981427000},"page":"e259716","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Buprenorphine \u2018microdosing\u2019 method for switching patients with opioid dependence from methadone to buprenorphine"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-1462","authenticated-orcid":false,"given":"Yesh Chandra","family":"Singh","sequence":"first","affiliation":[{"name":"National Drug Dependence Treatment Centre, All India Institute of Medical Sciences New Delhi, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Singh","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Centre, All India Institute of Medical Sciences New Delhi, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Bhad","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Centre, All India Institute of Medical Sciences New Delhi, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra","family":"Rao","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Centre, All India Institute of Medical Sciences New Delhi, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"2025082700560260000_17.11.e259716.1","unstructured":"Medications for Opioid Use Disorder . Treatment improvement protocol 63. Available: www.store.samhsa.gov\/pep21-02-01-002 [Accessed 25 Sep 2021]."},{"key":"2025082700560260000_17.11.e259716.2","unstructured":"Hanna M . Supporting recovery from opioid addiction: community care best practice guidelines for recovery-oriented methadone maintenance. Available: https:\/\/www.chestnut.org\/resources\/b903c6c4-4e53-46d8-acf0-37ef62b4e6ef\/Recovery-oriented-percent-20Methadone-percent-20Maintenance-percent-20Best-percent-20Practice-percent-20Guidelines-percent-202014-percent-20--percent-20CCBHO.pdf [Accessed 25 Sep 2024]."},{"key":"2025082700560260000_17.11.e259716.3","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S109919"},{"key":"2025082700560260000_17.11.e259716.4","unstructured":"Minitry of Health . A guideline for the clinical management of opioid use disorder. Available: https:\/\/www.bccsu.ca\/wp-content\/uploads\/2023\/12\/BC-OUD-Treatment-Guideline_2023-Update.pdf [Accessed 25 Sep 2023]."},{"key":"2025082700560260000_17.11.e259716.5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/jpm.2021.0378","article-title":"Buprenorphine Microdosing for the Pain and Palliative Care Clinician","volume":"25","author":"Quirk","year":"2022","journal-title":"J Palliat Med"},{"key":"2025082700560260000_17.11.e259716.6","unstructured":"Rao R , Ambekar A , Agrawal A . Methadone maintenance treatment under national aids control programme: practice guidelines. 2017. 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