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An analysis of the resulting specimen revealed a 50\u00d742\u00d715 mm smooth muscle neoplasm consistent with angioleiomyoma with a 22\u00d711\u2009mm entirely intralesional nodular component in keeping with a grade 1 leiomyosarcoma. The malignant constituent of the lesion was entirely encased in benign angioleiomyoma negating the need for further surgery. Systemic staging investigation revealed no evidence of metastatic disease spread final staging as per the eighth edition of the <jats:italic>American Joint Committee on Cancer<\/jats:italic> (AJCC) Staging T1N0M0 R0 Stage 1\u2009a.<\/jats:p>","DOI":"10.1136\/bcr-2024-259887","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T23:47:23Z","timestamp":1716421643000},"page":"e259887","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Intralesional leiomyosarcoma malignant transformation from a biopsied benign angioleiomyoma of the proximal anterior tibia"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-4324","authenticated-orcid":false,"given":"Thomas Robert William","family":"Ward","sequence":"first","affiliation":[{"name":"Trauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas C","family":"Eastley","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK"},{"name":"East Midlands Sarcoma Service, Leicester, UK"},{"name":"University of Leicester, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nomaan","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Trauma Orthopaedics, Kettering General Hospital, Kettering, Northamptonshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-2334","authenticated-orcid":false,"given":"Robert U","family":"Ashford","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK"},{"name":"East Midlands Sarcoma Service, Leicester, UK"},{"name":"University of Leicester, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"2025082707560428000_17.5.e259887.1","unstructured":"Morimoto N . n.d. 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Leiomyosarcoma. 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