{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:40:05Z","timestamp":1756366805530,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,9,5]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Nonepisodic angioedema with eosinophilia (NEAE) is characterised by a single episode of angioedema localised to the extremities and peripheral eosinophilia. While NEAE can develop in response to infection or vaccination, NEAE associated with acute parvovirus B19 (B19V) infection is rare. We describe the case of a young woman with NEAE that developed during acute B19V infection. She presented with 1-week history of pruritus and polyarthralgia in the extremities, followed by the development of peripheral oedema, and was positive for anti-B19V IgM antibody. Her arthralgia improved within 2\u2009weeks without any specific intervention; however, the oedema and pruritic erythema persisted and the peripheral eosinophil count increased. A short course of prednisolone therapy for suspected NEAE alleviated the symptoms, which have not recurred for more than 2 years. Thus, we believe that the patient was affected by NEAE and that NEAE can develop following acute B19 infection.<\/jats:p>","DOI":"10.1136\/bcr-2024-260006","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:27:29Z","timestamp":1726450049000},"page":"e260006","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Nonepisodic angioedema with eosinophilia subsequent to acute parvovirus B19 infection"],"prefix":"10.1136","volume":"17","author":[{"given":"Takahiro","family":"Minamii","sequence":"first","affiliation":[{"name":"General Internal Medicine, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-0646","authenticated-orcid":false,"given":"Hiroaki","family":"Nishioka","sequence":"additional","affiliation":[{"name":"General Internal Medicine, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"2025082800170261000_17.9.e260006.1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.4168\/aair.2014.6.4.362","article-title":"Clinical characteristics of angioedema with eosinophilia","volume":"6","author":"Cho","year":"2014","journal-title":"Allergy Asthma Immunol Res"},{"key":"2025082800170261000_17.9.e260006.2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4168\/aair.2020.12.2.371","article-title":"Non-episodic Angioedema With Eosinophilia Successfully Treated With Reslizumab","volume":"12","author":"Chu","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"2025082800170261000_17.9.e260006.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198406213102501"},{"key":"2025082800170261000_17.9.e260006.4","doi-asserted-by":"publisher","DOI":"10.1159\/000018025"},{"key":"2025082800170261000_17.9.e260006.5","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s10067-005-0023-2","article-title":"Nonepisodic angioedema with eosinophilia: a report of two cases and a review of the literature","volume":"25","author":"Matsuda","year":"2006","journal-title":"Clin Rheumatol"},{"key":"2025082800170261000_17.9.e260006.6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2332\/allergolint.11-OA-0351","article-title":"Eleven cases of angioedema with eosinophilia treated in a single hospital in Japan","volume":"61","author":"Nakachi","year":"2012","journal-title":"Allergol Int"},{"key":"2025082800170261000_17.9.e260006.7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1684\/ejd.2017.3123","article-title":"A case of non-episodic angioedema with eosinophilia induced by influenza vaccine","volume":"27","author":"Hayashi","year":"2017","journal-title":"Eur J Dermatol"},{"key":"2025082800170261000_17.9.e260006.8","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1111\/1346-8138.16626","article-title":"Non-episodic angioedema with eosinophilia developing after influenza vaccination: A case report","volume":"50","author":"Uesugi-Uchida","year":"2023","journal-title":"J Dermatol"},{"key":"2025082800170261000_17.9.e260006.9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/qjmed\/hcab245","article-title":"Non-episodic angioedema with eosinophilia after BNT162b2 mRNA COVID-19 vaccination","volume":"114","author":"Ishizuka","year":"2021","journal-title":"Q J M"},{"key":"2025082800170261000_17.9.e260006.10","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0990-1"},{"key":"2025082800170261000_17.9.e260006.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1995.tb02595.x"},{"key":"2025082800170261000_17.9.e260006.12","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.485-505.2002"},{"key":"2025082800170261000_17.9.e260006.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.02.044"},{"key":"2025082800170261000_17.9.e260006.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61894-7"},{"key":"2025082800170261000_17.9.e260006.15","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.34.163"},{"key":"2025082800170261000_17.9.e260006.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(01)00013-4"},{"key":"2025082800170261000_17.9.e260006.17","doi-asserted-by":"publisher","DOI":"10.1086\/514629"},{"key":"2025082800170261000_17.9.e260006.18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1182\/blood.V79.3.688.688","article-title":"Elevated serum levels of interleukin-5 in patients with the syndrome of episodic angioedema and eosinophilia","volume":"79","author":"Butterfield","year":"1992","journal-title":"Blood"},{"key":"2025082800170261000_17.9.e260006.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01445.x"},{"key":"2025082800170261000_17.9.e260006.20","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01514","article-title":"Interleukin-5 in the Pathophysiology of Severe Asthma","volume":"10","author":"Pelaia","year":"2019","journal-title":"Front Physiol"},{"key":"2025082800170261000_17.9.e260006.21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216799","article-title":"The effects of human parvovirus VP1 unique region in a mouse model of allergic asthma","volume":"14","author":"Chiang","year":"2019","journal-title":"PLoS One"},{"key":"2025082800170261000_17.9.e260006.22","doi-asserted-by":"crossref","DOI":"10.1093\/omcr\/omab137","article-title":"Non-episodic angioedema with eosinophilia, with increased serum level of interleukin-5 in a young Japanese woman","volume":"2022","author":"Usami","year":"2022","journal-title":"Oxf Med Case Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-260006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:17:15Z","timestamp":1756365435000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-260006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,13]]},"published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1136\/bcr-2024-260006"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-260006","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}