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We describe a case of a young man with autoimmune haemolytic anaemia secondary to systemic loxoscelism successfully treated with intravenous immunoglobulin and steroids.<\/jats:p>","DOI":"10.1136\/bcr-2024-260045","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:40:15Z","timestamp":1720831215000},"page":"e260045","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic loxoscelism leading to autoimmune haemolytic anaemia in a healthy young adult"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-8964","authenticated-orcid":false,"given":"Daniel","family":"Mai","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Iowa Health Care, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-3087","authenticated-orcid":false,"given":"Nirmal","family":"Muthukumarasamy","sequence":"additional","affiliation":[{"name":"Infectious Disease, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Ford","sequence":"additional","affiliation":[{"name":"Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-9419","authenticated-orcid":false,"given":"Poorani","family":"Sekar","sequence":"additional","affiliation":[{"name":"Infectious Disease, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"2025082723060131000_17.7.e260045.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62230-1"},{"key":"2025082723060131000_17.7.e260045.2","doi-asserted-by":"crossref","DOI":"10.1186\/s40409-017-0097-8","article-title":"Highlights in the knowledge of Brown spider toxins","volume":"23","author":"Chaves-Moreira","year":"2017","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"2025082723060131000_17.7.e260045.3","unstructured":"Jacob S . Brown Reclusespiders. Pennsylvania State University: Pennstate Extension; 2022. Available: https:\/\/extension.psu.edu\/brown-recluse-spiders"},{"key":"2025082723060131000_17.7.e260045.4","doi-asserted-by":"publisher","DOI":"10.1086\/341244"},{"key":"2025082723060131000_17.7.e260045.5","unstructured":"Anoka IA , Robb EL , Baker MB . Brown Recluse Spider Toxicity. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2023."},{"key":"2025082723060131000_17.7.e260045.6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molimm.2017.12.009","article-title":"Loxosceles venom Sphingomyelinase D activates human blood leukocytes: role of the complement system","volume":"94","author":"Manzoni-de-Almeida","year":"2018","journal-title":"Mol Immunol"},{"key":"2025082723060131000_17.7.e260045.7","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/ajcp\/aqab169","article-title":"Laboratory predictors of hemolytic anemia in patients with systemic Loxoscelism","volume":"157","author":"Jacobs","year":"2022","journal-title":"Am J Clin Pathol"},{"key":"2025082723060131000_17.7.e260045.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.07.021"},{"key":"2025082723060131000_17.7.e260045.9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/16078454.2022.2065086","article-title":"Systemic Loxoscelism induced warm autoimmune hemolytic anemia: clinical series and review","volume":"27","author":"Calhoun","year":"2022","journal-title":"Hematology"},{"key":"2025082723060131000_17.7.e260045.10","doi-asserted-by":"crossref","unstructured":"Nguyen N , Pandey M . Loxoscelism: cutaneous and hematologic manifestations. 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