{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:24:47Z","timestamp":1780655087434,"version":"3.54.1"},"reference-count":8,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,10,31]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin condition associated with the sudden onset of high-grade fever, painful rashes usually on the upper body, leukocytosis and neutrophilia. Approximately 21% of patients with Sweet syndrome have a concurrent malignancy, 80% of which are linked to haematological diseases, especially myelodysplastic syndrome and acute myeloid leukaemia. This is a case report of a woman in her 50s who was recently diagnosed with acute myeloid leukaemia and was started on decitabine 20\u2009mg\/m<jats:sup>2<\/jats:sup> (40\u2009mg). She complained of fever, multiple hyperpigmented nodules over her limbs with pus, swelling with erythema over the right eye and erosion over the tongue 2\u2009days after her first round of chemotherapy. The condition was diagnosed as Sweet syndrome owing to the presence of fever, leukocytosis, elevated erythrocyte sedimentation rate and neutrophil-dense infiltrates on skin biopsy. The patient was symptomatically treated, and decitabine was dechallenged. The patient started recovering after 4\u2009days and was discharged. On follow-up, chemotherapy with other agents were not reinitiated because of the adverse reaction which ultimately led to the patient\u2019s death.<\/jats:p>","DOI":"10.1136\/bcr-2024-260106","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T19:07:04Z","timestamp":1733857624000},"page":"e260106","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Decitabine-induced Sweet syndrome"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4809-0348","authenticated-orcid":false,"given":"Suryashri","family":"Krishnasamy","sequence":"first","affiliation":[{"name":"Pharmacy Practice, JSS College of Pharmacy, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-8903","authenticated-orcid":false,"given":"Acsah Annie","family":"Paul","sequence":"additional","affiliation":[{"name":"Pharmacy Practice, JSS College of Pharmacy, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"2025082722452853000_17.12.e260106.1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2011.1012"},{"key":"2025082722452853000_17.12.e260106.2","unstructured":"Vashisht P , Goyal A , Hearth Holmes MP . Sweet syndrome. In: StatPearls. Treasure Island, FL: StatPearls Publishing, 2024."},{"key":"2025082722452853000_17.12.e260106.3","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) . Acute Myeloid Leukemia version 4.2023. 2023."},{"key":"2025082722452853000_17.12.e260106.4","unstructured":"Uptodate . Sweet syndrome (acute febrile neutrophilic dermatosis): management and prognosis. n.d. Available: https:\/\/www.uptodate.com\/contents\/sweet-syndrome-acute-febrile-neutrophilic-dermatosis-management-and-prognosis"},{"key":"2025082722452853000_17.12.e260106.5","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00673-4"},{"key":"2025082722452853000_17.12.e260106.6","article-title":"Sweet Syndrome Associated with Myelodysplastic Syndrome-A Review of a Multidisciplinary Approach","volume":"13","author":"Ferea","year":"2023","journal-title":"Life (Basel)"},{"key":"2025082722452853000_17.12.e260106.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2022-252329","article-title":"Azacytidine-induced Sweet\u2019s syndrome","volume":"15","author":"Waghmare","year":"2022","journal-title":"BMJ Case Rep"},{"key":"2025082722452853000_17.12.e260106.8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199906)61:2<126::AID-AJH9>3.0.CO;2-8"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-260106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:45:42Z","timestamp":1756359942000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-260106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":8,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,10]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bcr-2024-260106"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-260106","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}