{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:41:56Z","timestamp":1762522916595,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,6,21]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Previous studies have linked persistent elevations in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) to cardiac abnormalities including aortic root dilation. Guidelines in the management of this dilation below the size recommended for surgery have not been well defined but follow-up and intervention when appropriate could be life-saving. We report the case of a man in his 60s who had been living with undiagnosed acromegaly for many years. His initial assessment through point-of-care ultrasound raised concerns about potential cardiac enlargement, prompting further investigation with a formal echocardiogram, which revealed a significant aortic root dilation measuring 4.5\u2009cm. Subsequent blood tests confirmed elevated levels of IGF-1. Brain MRI showed a focal lesion in the pituitary gland, which was surgically resected, confirming the diagnosis of a GH-secreting pituitary adenoma. One year after surgery, a repeat CT angiogram of the chest demonstrated a stable size of the aortic root aneurysm.<\/jats:p>","DOI":"10.1136\/bcr-2024-260204","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T23:40:31Z","timestamp":1720654831000},"page":"e260204","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Aortic root dilation in acromegaly"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6234-1983","authenticated-orcid":false,"given":"Yvette Ayewa","family":"Yeboah-Kordieh","sequence":"first","affiliation":[{"name":"Internal Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqar","family":"Arif","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5082-8955","authenticated-orcid":false,"given":"David","family":"Weisman","sequence":"additional","affiliation":[{"name":"Internal Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Salvatori","sequence":"additional","affiliation":[{"name":"Johns Hopkins Pituitary Center, Johns Hopkins Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"2025082710214896000_17.7.e260204.1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes 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